Polymorphisms of Vitamin D Receptor and Survival in Early-Stage Non-Small Cell Lung Cancer Patients

Details

• Personal Author:
  Asomaning K ; Christiani, David C. ; Giovannucci E ; Heist RS ; Liu G ; Lynch TJ ; Neuberg DS ; Su L ; Wain JC ; Zhou W
• Description:
  Our previous analysis suggested that surgery season in the summer time and high vitamin D intake are associated with improved survival in early-stage non-small cell lung cancer (NSCLC) patients. Here, we investigated the associations of vitamin D receptor (VDR) polymorphisms of Cdx-2 G>A, FokI C>T, and BsmI C>T with overall survival (OS) and recurrence-free survival (RFS) in 373 early-stage NSCLC patients. The data were analyzed using log-rank test and Cox proportional hazards models. The median follow-up time was 71 months (range, 0.1-140 months), with 186 deaths and 127 recurrences. There was no association between VDR polymorphisms and survival, overall or among adenocarcinoma patients. Among squamous cell carcinoma (SCC) patients, the G/A+A/A genotype group of the Cdx-2 polymorphism was associated with better OS: the 5-year OS rates were 41% [95% confidence interval (95% CI), 28-53] for the G/G and 55% (95% CI, 39-71) for the G/A+A/A genotypes, respectively (P = 0.04, log-rank test), with the adjusted hazard ratio of 0.56 (95% CI, 0.33-0.95) for G/A+A/A versus G/G. For the joint effects of the three polymorphisms, subjects with two or more "protective" alleles have better OS among SCC patients, with the adjusted hazard ratios of 0.20 (95% CI, 0.09-0.48), 0.40 (95% CI, 0.19-0.87), and 0.43 (95% CI, 0.19-0.97), respectively, for subjects with two, three, and four or more "protective" alleles when compared with subjects with zero or one "protective" allele (P(trend) = 0.71). Similar associations were found in haplotype analysis and for RFS among SCC patients. In conclusion, VDR polymorphisms may be associated with improved survival among SCC patients of early-stage NSCLC. [Description provided by NIOSH]
• Subjects:
  Aging Environmental Exposure Lung Lung Diseases Men Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smokers Women

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• Keywords:
  Age Groups Cancer Carcinomas Exposure Levels Hazards Health Effects Humans Lung Cancer Models Risk Factors Secondhand Smoke Smoking Statistical Analysis

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• ISSN:
  1055-9965
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  15
• Issue:
  11
• NIOSHTIC Number:
  nn:20060030
• Citation:
  Cancer Epidemiol Biomark Prev 2006 Nov; 15(11):2239-2245
• Contact Point Address:
  Wei Zhou, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115
• Email:
  wzhou@hsph.harvard.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Cancer Epidemiology, Biomarkers & Prevention
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:986394743761379b2cf53047b9b8078b3a7a07fc89f41ec6342cf94f35c76f0edbeb4d1b248b96a28b6e98524d32b6325aaa61a8ef88beb95bbc544ef24a583c
• Download URL:
  https://stacks.cdc.gov/view/cdc/224067/cdc_224067_DS1.pdf
• File Type:
  [PDF - 267.22 KB ]