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Portable XRF Technology to Quantify Pb in Bone In Vivo



Details

  • Personal Author:
  • Description:
    Lead is a ubiquitous toxicant. Bone lead has been established as an important biomarker for cumulative lead exposures and has been correlated with adverse health effects on many systems in the body. K-shell X-ray fluorescence (KXRF) is the standard method for measuring bone lead, but this approach has many difficulties that have limited the widespread use of this exposure assessment method. With recent advancements in X-ray fluorescence (XRF) technology, we have developed a portable system that can quantify lead in bone in vivo within 3 minutes. Our study investigated improvements to the system, four calibration methods, and system validation for in vivo measurements. Our main results show that the detection limit of the system is 2.9ppm with 2mm soft tissue thickness, the best calibration method for in vivo measurement is background subtraction, and there is strong correlation between KXRF and portable LXRF bone lead results. Our results indicate that the technology is ready to be used in large human population studies to investigate adverse health effects of lead exposure. The portability of the system and fast measurement time should allow for this technology to greatly advance the research on lead exposure and public/environmental health. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    2090-8660
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    2014
  • NIOSHTIC Number:
    nn:20054079
  • Citation:
    J Biomark 2014 Nov; 2014:398032
  • Contact Point Address:
    Linda Huiling Nie, School of Health Sciences, Purdue University,West Lafayette, IN 47907, USA
  • Email:
    hnie@purdue.edu
  • CAS Registry Number:
    Lead (CAS RN 7439-92-1)
  • Federal Fiscal Year:
    2015
  • Performing Organization:
    Purdue University, West Lafayette, Indiana
  • Peer Reviewed:
    True
  • Start Date:
    20120701
  • Source Full Name:
    Journal of Biomarkers
  • End Date:
    20150630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:abdba4a0123106257534b0847430e40f35d46aa2facb26eb6d0f72160d7ca695d4155337112078ce80a88ef0a7a741a7709bbf7f690c81fa6c8746114d4406d9
  • Download URL:
  • File Type:
    Filetype[PDF - 1.67 MB ]
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