Bone Lead Variability in Bone Repository Skeletal Samples Measured with Portable X-Ray Fluorescence

Details

• Personal Author:
  Bartell SM ; Davis M ; Specht AJ ; Steadman DW ; Weisskopf MG
• Description:
  Bone lead serves as a better, more accessible biomarker to many communities experiencing chronic exposure to lead. A new method using low energy x-ray fluorescence in a handheld device (portable XRF) allows us to measure this chronic biomarker in only a few minutes. However, many unknowns remain about this biomarker measured using a new low energy x-ray technique. The low energy of the new method was theorized to measure a slightly different portion of the bone than previous techniques, which could influence measurements at different bone sites and types. We tested how bone measurements varied across five bone sites: mid-tibial shaft, proximal tibia, distal tibia (ankle), ilium, and cranium. We found bone lead measurements are not significantly different between skeletal elements when measured using a portable XRF. On average, bone lead in the repository samples was measured to be 21.6 +/- 21.3 µg/g with an XRF detection limit of 2.1 +/- 0.5 µg/g. Cumulative lead exposure can be effectively measured using the portable XRF on a variety of bone types, but the tibia should be preferentially measured to compare between studies and individuals. [Description provided by NIOSH]
• Subjects:
  Biomarkers Lead Occupational Exposure Occupational Health Safety
• Keywords:
  Author Keywords: Bone Lead Biological Monitoring Bone Bone Structure Chronic Chronic Exposure Emerging Technology Tibia X-ray Fluorescence Analysis XRF
• ISSN:
  0048-9697
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Indiana ; Massachusetts ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9 ; Tennessee
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  880
• NIOSHTIC Number:
  nn:20067692
• Citation:
  Sci Total Environ 2023 Jul; 880:163197
• Contact Point Address:
  Aaron J. Specht, School of Health Sciences, Purdue University, West Lafayette, IN, United States of America
• Email:
  aspecht@purdue.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2023
• Performing Organization:
  Purdue University
• Peer Reviewed:
  True
• Start Date:
  20210901
• Source Full Name:
  Science of the Total Environment
• End Date:
  20220731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f6375a84a754ef7b8ac83df2c778fc38a3d6085c24c33cc2690c3d924bc2eee80a48ded17692ec2cdc9e1ae0470a25ba275590815a2e484c87cbeffe2fc5c30c
• Download URL:
  https://stacks.cdc.gov/view/cdc/229955/cdc_229955_DS1.pdf
• File Type:
  [PDF - 1.87 MB ]