Community Exposure to Perfluorooctanoate: Relationships Between Serum Levels and Certain Health Parameters

Details

• Personal Author:
  Desai C ; Emmett, Edward A. ; Freeman D ; Rodway NV ; Shaw LM ; Shofer FS ; Zhang H
• Description:
  Objective: The objective of this study was to determine whether certain biomarkers of toxicity and/or a past diagnosis of liver or thyroid disease were associated with serum perfluorooctanoate concentrations (PFOA) in a community with longstanding environmental exposure to PFOA. Methods: Serum (PFOA), hematologic and biochemical biomarkers, and a questionnaire were administered to 371 residents selected by stratified random sampling and a lottery among volunteers. Median PFOA was 354 ng/mL (interquartile range, 181-571 ng/mL). Results: No significant positive relationships between serum (PFOA) and liver or renal function tests, cholesterol, thyroid-stimulating hormone, or with red cell indices, white cell, or platelet counts. Mean serum (PFOA) was not increased in those with a history of liver or thyroid disease. Conclusions: No toxicity from PFOA was demonstrated using the measured end points; other end points need to be addressed. [Description provided by NIOSH]
• Subjects:
  Biomarkers Environmental Exposure Environmental Pollution Fluorocarbons Occupational Health Safety
• Keywords:
  Biological Effects Environmental Contamination Environmental Exposure Exposure Assessment Health Effects Liver Disease Thyroid Gland Disorders
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  48
• Issue:
  8
• NIOSHTIC Number:
  nn:20053502
• Citation:
  J Occup Environ Med 2006 Aug; 48(8):771-779
• Contact Point Address:
  Edward A. Emmett, MD, Occupational Medicine, Silverstein Pavilion, Ground Floor, 3400 Spruce St., Philadelphia, PA 19104-4284
• Email:
  emmetted@mail.med.upenn.edu
• CAS Registry Number:
  Perfluorooctanoic acid (CAS RN 335-67-1)
• Federal Fiscal Year:
  2006
• Performing Organization:
  University of Pennsylvania, Philadelphia
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a3b93c46018e55cbec82b1107e90790aaa0bba520fb83e5c3cdebb52c2cca53b15802d181b74eff73cb27c10188d5225522cc0e0f57486b3d58665d8d7764615
• Download URL:
  https://stacks.cdc.gov/view/cdc/216242/cdc_216242_DS1.pdf
• File Type:
  [PDF - 272.07 KB ]