Pyrethroid Insecticide Metabolites Are Associated with Serum Hormone Levels in Adult Men

Details

• Personal Author:
  Barr DB ; Hauser R ; Meeker JD
• Description:
  Experimental studies have reported that pyrethroid insecticides affect male endocrine and reproductive function, but human data are limited. We recruited 161 men from an infertility clinic between years 2000-2003 and measured serum reproductive and thyroid hormone levels, as well as the pyrethroid metabolites 3-phenoxybenzoic acid (3PBA) and cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (cis-DCCA and trans-DCCA) in spot urine samples. When adjusting for potential confounders, categories for all three metabolites, as well as their summed values, were positively associated with FSH (all p-values for trend <0.05). Statistically significant or suggestive positive relationships with LH were also found. In addition, cis-DCCA and trans-DCCA were inversely associated with inhibin B (p for trend=0.03 and 0.02, respectively). Finally, there was evidence that trans-DCCA was inversely associated with testosterone and free androgen index (the ratio of testosterone to sex hormone binding globulin; p for trend=0.09 and 0.05, respectively). The observed relationships were consistent with previous findings, but further research is needed for a better understanding of the potential association between pyrethroid insecticides and male reproduction. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Endocrine System Energy Metabolism Environment Environmental Exposure Epidemiology Insecticides Men Occupational Health Risk Assessment Risk Factors Safety Urine Urogenital System

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• Keywords:
  Author Keywords: Biomarkers Benzoates Endocrine Disruption Endocrine Function Environmental Exposure Exposure Exposure Levels Health Effects Hormones Humans Metabolites Permethrin Pesticide Pesticides Pyrethroids Reproduction Risk Factors Urinalysis

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• ISSN:
  0890-6238
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; OSHA Region 1 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  155-160
• Volume:
  27
• Issue:
  2
• NIOSHTIC Number:
  nn:20057781
• Citation:
  Reprod Toxicol 2009 Apr; 27(2):155-160
• Contact Point Address:
  John D. Meeker, Department of Environmental Health Sciences, University of Michigan School of Public Health, 6635 SPH Tower, 109 S. Observatory St., Ann Arbor, MI 48109
• Email:
  meekerj@umich.edu
• CAS Registry Number:
  3-Phenoxybenzoic acid (CAS RN 3739-38-6)
• Federal Fiscal Year:
  2009
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Reproductive Toxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1a4e91baa36363cc84cac012a8cb59087db7d554eee2f71d8486cce6138ffe83782b224fbedd11abde37d94c31b049c0e0ee1c2e9f7a1cbf993825ef83f9219d
• Download URL:
  https://stacks.cdc.gov/view/cdc/215013/cdc_215013_DS1.pdf
• File Type:
  [PDF - 160.78 KB ]