Human Semen Quality and Sperm DNA Damage in Relation to Urinary Metabolites of Pyrethroid Insecticides

Details

• Personal Author:
  Barr DB ; Hauser R ; Meeker JD
• Description:
  BACKGROUND: Exposure to synthetic pyrethroid insecticides is widespread, and is expected to increase among the general population due to the need to replace other common insecticides following regulatory use restrictions. On the basis of limited studies, there is animal and human evidence for altered reproductive or endocrine function following pyrethroid exposure. METHODS: The present study measured urinary pyrethroid metabolites [3-phenoxybenzoic acid (3PBA) and cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (CDCCA and TDCCA)], semen quality, sperm motion parameters and sperm DNA damage with the neutral comet assay in 207 men recruited from an infertility clinic. RESULTS: In multivariate analysis, the highest 3PBA quartile was associated with a suggestive 20.2 million sperm/ml reduction (95% confidence interval -37.1 to + 2.6) in sperm concentration compared with men below the 3PBA median. There were significant inverse associations between TDCCA and sperm motility and sperm motion parameters when adjusting for CDCCA and other covariates. The highest TDCCA quartile was associated with a 15.5% decline (95% confidence interval -26.2 to -4.8) in sperm motility compared with men below the median. In multiple logistic analyses, there were dose-dependent increased odds for below reference sperm concentration, motility and morphology in relation to TDCCA. Among the comet assay measures, 3PBA and CDCCA were associated with increased sperm DNA damage, measured as percent DNA in the comet tail. CONCLUSIONS: We found evidence for reduced semen quality and increased sperm DNA damage in relation to urinary metabolites of pyrethroid insecticides. These findings may be of concern due to increased pyrethroid use and prevalent human exposure. [Description provided by NIOSH]
• Subjects:
  Adolescent Energy Metabolism Environmental Exposure Insecticides Men Occupational Health Risk Assessment Risk Factors Safety Urine Urogenital System

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• Keywords:
  Adolescents Author Keywords: Biomarkers DNA Damage Drugs Endocrine Function Environmental Exposure Epidemiology Exposure Levels Humans Male Metabolism Metabolites Permethrin Pesticides Pyrethroids Reproduction Risk Factors Spermatozoa Statistical Analysis Urine Chemistry

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• ISSN:
  0268-1161
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; OSHA Region 1 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  23
• Issue:
  8
• NIOSHTIC Number:
  nn:20057778
• Citation:
  Hum Reprod 2008 Aug; 23(8):1932-1940
• Contact Point Address:
  John D. Meeker, Department of Environmental Health Sciences, University of Michigan School of Public Health, 6635 SPH Tower, 109 S. Observatory St., Ann Arbor, MI 48109
• Email:
  meekerj@umich.edu
• CAS Registry Number:
  3-Phenoxybenzoic acid (CAS RN 3739-38-6)
• Federal Fiscal Year:
  2008
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Human Reproduction
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:629a33f9cb93b25ef1d2be9dc2225dcf9e22fe5560a4157c0fae75a13160d85c3a12d3b7008baca4a3341da9e6ecdd523d27add65d4472f7d003370d7a537294
• Download URL:
  https://stacks.cdc.gov/view/cdc/215010/cdc_215010_DS1.pdf
• File Type:
  [PDF - 135.02 KB ]