Thyroid Hormones in Relation to Urinary Metabolites of Non-Persistent Insecticides in Men of Reproductive Age

Details

• Personal Author:
  Barr DB ; Hauser R ; Meeker JD
• Description:
  Human exposure to contemporary-use insecticides is widespread, but effects of exposure on human endocrine function have gone largely untested to date. Samples of urine and blood were collected concurrently from 322 adult men between the years 2000 and 2003. Urine samples were analyzed for 3,5,6-trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifos-methyl, and 1-napththol (1N), a metabolite of carbaryl and naphthalene. Serum samples were analyzed for free T4, total T3, and thyroid stimulating hormone (TSH). There was an association between TCPY and TSH, where an interquartile range (IQR) increase in TCPY was associated with a 9% (95% confidence interval 0-18%) increase in TSH. There was also a suggestive inverse association between TCPY and free T4. There were no associations between 1N and thyroid hormones. Environmental exposure to chlorpyrifos, chlorpyrifos-methyl, or its metabolite TCPY may be associated with altered thyroid function in human males. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Endocrine System Energy Metabolism Environmental Exposure Hematologic Tests Insecticides Men Occupational Health Risk Assessment Risk Factors Safety Urine

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• Keywords:
  Author Keywords: Biomarker Blood Sampling Carbaryl Chlorpyrifos Endocrine Endocrine Function Environmental Exposure Exposure Levels Hormone Hormones Humans Metabolites Naphthalene Pesticide Pesticides Risk Factors Sampling Thyroid Thyroid Gland Urinalysis

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• ISSN:
  0890-6238
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; OSHA Region 1 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  437-442
• Volume:
  22
• Issue:
  3
• NIOSHTIC Number:
  nn:20057774
• Citation:
  Reprod Toxicol 2006 Oct; 22(3):437-442
• Contact Point Address:
  John D. Meeker, Department of Environmental Health Sciences, University of Michigan, School of Public Health, M6226 SPH II, 109 S. Observatory St., Ann Arbor, MI 48109
• Email:
  meekerj@umich.edu
• CAS Registry Number:
  3,5,6-Trichloro-2-pyridinol (CAS RN 6515-38-4) ; Carbaryl (CAS RN 63-25-2)
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Reproductive Toxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ab54f83ec400cdf3dc92371453be4c32d251c3a2523c21e86562626f853d9eeb81f1ea0149241778e8a4b44c489c921ee38619e4e4588bca874897df76d964dc
• Download URL:
  https://stacks.cdc.gov/view/cdc/215007/cdc_215007_DS1.pdf
• File Type:
  [PDF - 178.63 KB ]