Distribution and Predictors of 20 Toxic and Essential Metals in the Umbilical Cord Blood of Chinese Newborns

Details

• Personal Author:
  Arain AL ; Chen M ; Lozoff B ; Meeker JD ; Shao J ; Silver MK ; Xia Y
• Description:
  Early-life exposure to heavy metals and/or trace metal imbalances can have negative developmental effects. Here we sought to characterize exposure profiles for 20 heavy metals and trace elements in umbilical cord blood plasma and identify demographic predictors of exposure. Twenty metals were measured in cord plasma from 357 Chinese infants using ICP-MS. Relationships between demographic variables and metals were analyzed using generalized linear models and logistic regression. Ten metals (antimony Sb, cobalt Co, cesium Cs, copper Cu, lead Pb, molybdenum Mo, rubidium Rb, selenium Se, strontium Sr, titanium Ti, zinc Zn) were detected in all samples. Season of birth was the strongest predictor of metals in cord blood across analyses. Infants born in the spring had 0.1-0.2 ug L-1 higher logAs and logCo in their cord blood (B 95%CI = 0.22 0.01,0.42, p = 0.04; 0.11 0.01,0.22, p = 0.04), while infants born in the summer had higher Sb, logB, logHg, and logZn (B 95%CI = 0.74 0.24,1.24, p = 0.004; 0.11 0.00,0.21, p = 0.04; 0.29 0.08,0.49, p = 0.007; 0.18 0.06,0.31, p = 0.005), compared to those born in fall/winter. Prenatal heavy metal exposure and/or trace metal deficiencies are global concerns because of increasing awareness of downstream developmental effects. Description provided by NIOSH
• Subjects:
  • Metals
  • Metals, Heavy
  • Occupational Health
  • Pregnancy
  • Safety
• Keywords:
  • Trace metals
  • Heavy metals
  • Pregnancy
  • Prenatal exposure
  • Developmental disorders
  • Author Keywords: Metals
  • Prenatal exposure
  • Cord blood
  • China
  • Neonate
• ISSN:
  0045-6535
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  210
• NIOSHTIC Number:
  nn:20055711
• Citation:
  Chemosphere 2018 Nov; 210:1167-1175
• Contact Point Address:
  John D. Meeker, University of Michigan School of Public Health, 1835 SPH 1, 1415 Washington Heights, Ann Arbor, MI 48109, USA
• Email:
  meekerj@umich.edu
• CAS Registry Number:
  • Antimony (CAS RN 7440-36-0)
  • Cobalt (CAS RN 7440-48-4)
  • Copper (CAS RN 7440-50-8)
  • Lead (CAS RN 7439-92-1)
  • Molybdenum (CAS RN 7439-98-7)
  • Selenium (CAS RN 7782-49-2)
  • Strontium (CAS RN 7440-24-6)
  • Titanium (CAS RN 7440-32-6)
  • Zinc (CAS RN 7440-66-6)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Chemosphere
• End Date:
  20280630
• Download URL:
  https://stacks.cdc.gov/view/cdc/213499/cdc_213499_DS1.pdf
• File Type:
  [PDF - 915.65 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5751208073a0ddbd875427f821d1c6fe3c107178f9135b3823a62e6d42dc6160fa34e5ae42a8782898932b6eec49e89d5795545bf783ecc2bfda3ad43917742e