DNA Methylation Changes Associated with Prenatal Mercury Exposure: A Meta-Analysis of Prospective Cohort Studies from PACE Consortium

Details

• Personal Author:
  Annesi-Maesano I ; Bakulski KM ; Ballester F ; Broberg K ; Bustamante M ; Dou JF ; Fallin MD ; Gutzkow KB ; Haug LS ; Hivert M-F ; Huel G ; Ikeda-Araki A ; Kim WJ ; Kishi R ; Llop S ; Lozano M ; Miyashita C ; Oken E ; Park J ; Pesce G ; Rahman M ; Relton C ; Rifas-Shiman S ; Soler-Blasco R ; Vafeiadi M ; Vrijheid M ; Won S ; Yousefi P
• Description:
  Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg exposure can alter epigenetic modifications during embryogenesis. In this study, we examined associations between prenatal MeHg exposure and levels of cord blood DNA methylation (DNAm) by meta-analysis in up to seven independent studies (n = 1462) as well as persistence of those relationships in blood from 7 to 8 year-old children (n = 794). In cord blood, we found limited evidence of differential DNAm at cg24184221 in MED31 (β = 2.28 × 10-4, p-value = 5.87 × 10-5) in relation to prenatal MeHg exposure. In child blood, we identified differential DNAm at cg15288800 (β = 0.004, p-value = 4.97 × 10-5), also located in MED31. This repeated link to MED31, a gene involved in lipid metabolism and RNA Polymerase II transcription function, may suggest a DNAm perturbation related to MeHg exposure that persists into early childhood. Further, we found evidence for association between prenatal MeHg exposure and child blood DNAm levels at two additional CpGs: cg12204245 (ß = 0.002, p-value = 4.81 × 10-7) in GRK1 and cg02212000 (ß = -0.001, p-value = 8.13 × 10-7) in GGH. Prenatal MeHg exposure was associated with DNAm modifications that may influence health outcomes, such as cognitive or anthropometric development, in different populations. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Environmental Exposure Mercury Metals, Heavy Occupational Health Pregnancy Safety
• Keywords:
  ALSPAC Author Keywords: DNA Methylation Cohort Studies DNA Damage Environmental Exposure Heavy Metals HELIX Study Methylmercury PACE Prenatal Exposure
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  204
• NIOSHTIC Number:
  nn:20070648
• Citation:
  Environ Res 2022 Mar; 204(Pt B):112093
• Contact Point Address:
  Manuel Lozano, Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, Universitat de València, Av. Vicent Andrés Estellés s/n, 46100, Burjassot, Spain
• Email:
  manuel.lozano@uv.es
• CAS Registry Number:
  Mercury (CAS RN 7439-97-6) ; Methylmercury(1+) (CAS RN 22967-92-6)
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Part Number:
  B
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:75baed7cffb1862d4662288aceb43442eaaf178f623700158652b5299486c75f1a3fd98a1af33d56d7d32b543f90d8d4507c550102fd190b91c105beb0db6a2f
• Download URL:
  https://stacks.cdc.gov/view/cdc/208826/cdc_208826_DS1.pdf
• File Type:
  [PDF - 3.88 MB ]