Details:

Alternative Title:
Chemosphere
Personal Author:
Silver, Monica K ; Langeland, Aubrey L ; Shao, Jie ; Chen, Minjian ; Xia, Yankai ; ... More +
Silver, Monica K ; Langeland, Aubrey L ; Shao, Jie ; Chen, Minjian ; Xia, Yankai ; Lozoff, Betsy ; Meeker, John D Less -
Description:
Early-life exposure to heavy metals and/or trace metal imbalances can have negative developmental effects. Here we sought to characterize exposure profiles for 20 heavy metals and trace elements in umbilical cord blood plasma and identify demographic predictors of exposure. Twenty metals were measured in cord plasma from 357 Chinese infants using ICP-MS. Relationships between demographic variables and metals were analyzed using generalized linear models and logistic regression. Ten metals (antimony [Sb], cobalt [Co], cesium [Cs], copper [Cu], lead [Pb], molybdenum [Mo], rubidium [Rb], selenium [Se], strontium [Sr], titanium [Ti], zinc [Zn]) were detected in all samples. Season of birth was the strongest predictor of metals in cord blood across analyses. Infants born in the spring had 0.1-0.2 μg L-1 higher logAs and logCo in their cord blood (β [95%CI] = 0.22 [0.01,0.42], p = 0.04; 0.11 [0.01,0.22], p = 0.04), while infants born in the summer had higher Sb, logB, logHg, and logZn (β [95%CI] = 0.74 [0.24,1.24], p = 0.004; 0.11 [0.00,0.21], p = 0.04; 0.29 [0.08,0.49], p = 0.007; 0.18 [0.06,0.31], p = 0.005), compared to those born in fall/winter. Prenatal heavy metal exposure and/or trace metal deficiencies are global concerns because of increasing awareness of downstream developmental effects.
Subject:
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Article
Asian Continental Ancestry Group
Female
Fetal Blood/chemistry
Humans
Infant, Newborn
Metals, Heavy/adverse Effects
Metals, Heavy/blood
Pregnancy
Trace Elements/adverse Effects
Trace Elements/toxicity

Source:
Chemosphere. 210:1167-1175
Pubmed ID:
30208542
Pubmed Central ID:
PMC6179361
Document Type:
Journal Article
Funding:
P01 HD039386/HD/NICHD NIH HHS/United States ; P30 ES017885/ES/NIEHS NIH HHS/United States ; R01 ES021465/ES/NIEHS NIH HHS/United States ; T42 OH008455/OH/NIOSH CDC HHS/United States
P01 HD039386/HD/NICHD NIH HHS/United States ; P30 ES017885/ES/NIEHS NIH HHS/United States ; R01 ES021465/ES/NIEHS NIH HHS/United States ; T42 OH008455/OH/NIOSH CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:122ee5ad15500fa58bbcc03422d651b6c97e5eae751b1fbca943bc949f84cece
File Type:

Supporting Files

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  	NIHMS990634-supplement-1.docx	docx

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