Organophosphorous Pesticide Exposure and Neurobehavioral Performance Among Adolescents in Egypt: A Ten-Month Prospective Study

Details

• Personal Author:
  Bonner MR ; Hendy O ; Ismail AA ; Mara K ; Olson JR ; Rasoul GA ; Rohlman DS ; Wang K
• Description:
  Chlorpyrifos, an organophosphorus pesticide, is widely used for agricultural operations. The goal of the current study was to examine the impact of chlorpyrifos exposure on biomarkers of exposure and neurobehavioral performance in adolescents before, during and after the application season. At each test session, participants (N=89) completed a neurobehavioral test battery and urine was collected for analysis of the chlorpyrifos metabolite 3,5,6-trichloro-2 pyridinol (TCPy) (biomarker of exposure). Cumulative urinary TCPy over the study period was used to classify participants into low (< median) and high (>/= median) exposure groups. Urinary TCPy increased during the application season with recovery following the end of application. Participants in the high exposure group had significantly elevated metabolite levels throughout the 10-month study period. Deficits in motor skills and slower reaction times, along with deficits in executive function and short-term memory were found between the high and low exposure groups. Changes in neurobehavioral performance across the application season indicate a pattern of impaired performance in the high exposure group compared to the low exposure group. Deficits increased during the application season and remained for months after application ended. This study is the first to examine the impact of changes in pesticide exposure and neurobehavioral performance before, during and after the application season. The findings indicate that neurobehavioral deficits increase during the application season, as exposure also increases, and remain after the application ends, even when the biomarkers of exposure are reduced. This is particularly important when considering the developmental changes that occur during adolescence. [Description provided by NIOSH]
• Subjects:
  Adolescent Biomarkers Environmental Exposure Insecticides Occupational Health Organophosphates Safety
• Keywords:
  Adolescents Exposure Levels Neurological System Neurophysiological Effects Organophosphorus Pesticides Pesticides And Agricultural Chemicals
• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Abstract or Summary
• Place as Subject:
  Iowa ; New York ; OSHA Region 2 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  150
• Issue:
  1
• NIOSHTIC Number:
  nn:20052814
• Citation:
  Toxicologist 2016 Mar; 150(1):331
• CAS Registry Number:
  3,5,6-Trichloro-2-pyridinol (CAS RN 6515-38-4) ; Chlorpyrifos (CAS RN 2921-88-2)
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Iowa, Iowa City
• Peer Reviewed:
  False
• Start Date:
  20010930
• Source Full Name:
  The Toxicologist. Society of Toxicology 55th Annual Meeting and ToxExpo, March 13-17, 2016, New Orleans, Louisiana
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9010a4e70283ced8f56102395432d68a5f337efbc7ad49725be0a27cee61624ef2eb4839e6f1b1a0a2fd1aae155563c9d8591a09d4988fc10bc4ee4f5a7c0e63
• Download URL:
  https://stacks.cdc.gov/view/cdc/212283/cdc_212283_DS1.pdf
• File Type:
  [PDF - 515.43 KB ]