Occupational Pesticide Exposure and Parental Report of Attention Deficit Hyperactivity Disorder in Adolescent Pesticide Applicators in Egypt

Details

• Personal Author:
  Bonner MR ; Hendy O ; Ismail A ; Olson JR ; Ortega L ; Rasoul GA ; Rohlman DS ; Wang K
• Description:
  Exposure to environmental chemicals, including organophosphorus pesticides, has been associated with attention disorders such as attention deficit hyperactivity disorder (ADHD). Previous studies have identified associations between ADHD and prenatal exposures; additionally one cross-sectional study reported an association between organophosphate metabolite levels and a diagnosis of ADHD among school-age children. However, the impact of occupational pesticide exposure and ADHD in adolescents has not been examined. Adolescent pesticide applicators and non-applicators, 12-18 years old, participated in a 10- month longitudinal study examining health effects from pesticide exposure before, during and after the application season. Parents from a subset of the cohort (N=64) completed the ADHD Rating Scale. Repeated urine and blood samples were collected at various time points during the 10-months to assess biomarkers of exposure and effect. Cumulative urinary TCPy over the study period was used to classify participants into low (< median) and high (. median) exposure groups. Participants in the high exposure group had significantly more symptoms of ADHD than participants in the low exposure group. The prevalence odds ratio of having symptoms greater than the cut off in the high exposure group was 2.8 (95% CI = 0.5-14.7) times the odds in the low exposure group. More participants with symptoms above the cut-off score reported applying pesticides at home and had greater cumulative TCPy levels, than participants with symptoms below the cut-off score. However, there were no differences between the groups on years worked as a pesticide applicator for the Ministry of Agriculture. Although limited by a small sample size, this study provides preliminary evidence of an association between occupational pesticide exposure and ADHD symptoms, however, additional research is warranted. [Description provided by NIOSH]
• Subjects:
  Biomarkers Environmental Exposure Insecticides Occupational Health Organophosphates Pregnancy Safety
• Keywords:
  Environmental Exposure Longitudinal Study Organophosphorus Pesticides Pesticides And Agricultural Chemicals Prenatal Exposure Risk Assessment
• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Abstract or Summary
• Place as Subject:
  Iowa ; New York ; OSHA Region 2 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  150
• Issue:
  1
• NIOSHTIC Number:
  nn:20052812
• Citation:
  Toxicologist 2016 Mar; 150(1):331
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Iowa, Iowa City
• Peer Reviewed:
  False
• Start Date:
  20010930
• Source Full Name:
  The Toxicologist. Society of Toxicology 55th Annual Meeting and ToxExpo, March 13-17, 2016, New Orleans, Louisiana
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c9e4935b3a9ec07193b726560e0c94f033ce9e8a2ae471c72f162619bd8e463ab5235e6c7fc6db488bd0953e044894d659f8327c4d4bf976e014f146011c9438
• Download URL:
  https://stacks.cdc.gov/view/cdc/212282/cdc_212282_DS1.pdf
• File Type:
  [PDF - 515.41 KB ]