Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions

Details

• Personal Author:
  Arble DM ; Bass J ; Butler MP ; Challet E ; Czeisler, Charles A. ; Depner CM ; Diniz Behn C ; Elmquist J ; Franken P ; Grandner MA ; Hanlon EC ; Joyner MJ ; Karatsoreos I ; Keene AC ; Kern PA ; Klein S ; Morris CJ ; Pack AI ; Panda S ; Ptacek LJ ; Punjabi NM ; Sassone-Corsi P ; Saxena R ; Scheer FA ; Seaquest ER ; Thimgan MS ; Van Cauter E ; Wright KP
• Description:
  A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes. The workshop identified a number of key principles for research in this area and a number of specific opportunities. Studies in this area would be facilitated by active collaboration between investigators in sleep/circadian research and investigators in metabolism/diabetes. There is a need to translate the elegant findings from basic research into improving the metabolic health of the American public. There is also a need for investigators studying the impact of sleep/circadian disruption in humans to move beyond measurements of insulin and glucose and conduct more in-depth phenotyping. There is also a need for the assessments of sleep and circadian rhythms as well as assessments for sleep-disordered breathing to be incorporated into all ongoing cohort studies related to diabetes risk. Studies in humans need to complement the elegant short-term laboratory-based human studies of simulated short sleep and shift work etc. with studies in subjects in the general population with these disorders. It is conceivable that chronic adaptations occur, and if so, the mechanisms by which they occur needs to be identified and understood. Particular areas of opportunity that are ready for translation are studies to address whether CPAP treatment of patients with pre-diabetes and obstructive sleep apnea (OSA) prevents or delays the onset of diabetes and whether temporal restricted feeding has the same impact on obesity rates in humans as it does in mice. [Description provided by NIOSH]
• Subjects:
  Blood Circadian Rhythm Energy Metabolism Hematologic Diseases Occupational Health Safety Shift Work Schedule Sleep Sleep Initiation And Maintenance Disorders
• Keywords:
  Author Keywords: Circadian Disruption Blood Sugar Disorders Circadian Rhythm Circadian Rhythms Clinical Pathology Diabetes Hormone Activity Insulin Resistance Metabolic Effects Metabolism Obesity Shift Work Short Sleep Sleep Apnea Sleep Deprivation Sleep Disorders

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• ISSN:
  0161-8105
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; Colorado ; Illinois ; Kentucky ; Massachusetts ; Michigan ; Minnesota ; Nevada ; Oregon ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 8 ; OSHA Region 9 ; Pennsylvania ; Texas ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  38
• Issue:
  12
• NIOSHTIC Number:
  nn:20052725
• Citation:
  Sleep 2015 Dec; 38(12):1849-1860
• Contact Point Address:
  Allan I. Pack, MBChB, PhD, Center for Sleep and Circadian Neurobiology, 125 South 31st Street, Suite 2100, Philadelphia, PA 19104-3403
• Email:
  pack@mail.med.upenn.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Chicago
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Sleep
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e83a07701c2deb1bffd25ea83ea77774b9cd5e02dba51e935da48158b91d45009c1fa8dbf862b730a62452d342f6f78aec9e0d7a3ddd196f1a77e080733996a4
• Download URL:
  https://stacks.cdc.gov/view/cdc/212205/cdc_212205_DS1.pdf
• File Type:
  [PDF - 475.17 KB ]