Interactions Between Sleep, Circadian Function, and Glucose Metabolism: Implications for Risk and Severity of Diabetes

Details

• Personal Author:
  Reutrakul S ; Van Cauter E
• Description:
  Sleep disturbances, including sleep insufficiency and sleep fragmentation, have been linked to abnormal glucose metabolism and increased diabetes risk. Well-controlled laboratory studies have provided insights regarding the underlying mechanisms. Several large prospective studies suggest that these sleep disturbances are associated with an increased risk of incident diabetes. Obstructive sleep apnea, which combines sleep fragmentation and hypoxemia, is a major risk factor for insulin resistance and possibly diabetes. Whether glycemic control in type 2 diabetes patients can be improved by treating sleep apnea remains controversial. Recently, sleep disturbances during pregnancy and their relationship to gestational diabetes and hyperglycemia have received considerable attention owing to potential adverse effects on maternal and fetal health. Additionally, evidence from animal models has identified disruption of the circadian system as a putative risk factor for adverse metabolic outcomes. The purpose of this review is to provide an update on the current state of knowledge linking sleep disturbances, circadian dysfunction, and glucose metabolism. Experimental, prospective, and interventional studies are discussed. [Description provided by NIOSH]
• Subjects:
  Blood Circadian Rhythm Energy Metabolism Hematologic Diseases Occupational Health Safety Sleep Sleep Initiation And Maintenance Disorders
• Keywords:
  Author Keywords: Sleep Blood Sugar Disorders Circadian Rhythms Diabetes Glucose Metabolism Hormone Activity Metabolic Effects Sleep Apnea Sleep Disorders
• ISSN:
  0077-8923
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  151-173
• Volume:
  1311
• Issue:
  1
• NIOSHTIC Number:
  nn:20052744
• Citation:
  Ann NY Acad Sci 2014 Apr; 1311(1):151-173
• Contact Point Address:
  Sirimon Reutrakul, M.D., CDE, Division of Endocrinology and Metabolism, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Ratchathewi, Bangkok 10400, Thailand
• Email:
  sreutrak10800@gmail.com
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Chicago
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Annals of the New York Academy of Sciences
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9c68dd4154e290c620f773e5051b5226cdb115e1bfaf155a5d8b23e6750ef50312cc20ebfc7d4b51c08ff32a8b2db2d74cf8e0cf46980ba71ac52dca0560f379
• Download URL:
  https://stacks.cdc.gov/view/cdc/212222/cdc_212222_DS1.pdf
• File Type:
  [PDF - 770.67 KB ]