Consequences of Circadian Disruption on Cardiometabolic Health

Details

• Personal Author:
  Knutson KL ; Reutrakul S
• Description:
  Cardiovascular disease (CVD), diabetes, and obesity affect millions of people worldwide and the rates of these cardiometabolic diseases are on the rise. Cardiometabolic diseases are associated with reduced quality of life, lower life expectancy, and increased economic burden on both the individual and on society. Therefore, thorough understanding of all the risk factors for these diseases could contribute to improvement in global health. This article discusses a potentially novel risk factor for cardiometabolic disease: circadian disruption. Circadian disruption occurs when the endogenous circadian (w24-hour) rhythms are not in synchrony with either the environment or each other. This desynchrony can occur when behaviors such as wake, sleep, and meals are not at an appropriate time relative to the timing of the central circadian clock, which is located in the hypothalamus, and/or relative the external environment, particularly the light-dark cycle. This article reviews studies that examined cardiometabolic health of shift work, which typically leads to circadian disruption; studies that experimentally disrupted circadian rhythms to determine the effects on cardiometabolic function; and observational studies that examined sleep timing and behavioral chronotype. A few potential mediators linking the chronotype and shift work to circadian disruption and cardiometabolic health are briefly discussed. [Description provided by NIOSH]
• Subjects:
  Blood Cardiovascular Diseases Cardiovascular System Circadian Rhythm Energy Metabolism Hematologic Diseases Occupational Health Safety Shift Work Schedule Sleep Sleep Initiation And Maintenance Disorders

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• Keywords:
  Author Keywords: Circadian Rhythms Blood Sugar Disorders Cardiovascular Disease Circadian Rhythms Diabetes Heart Disease Metabolic Effects Shift Work Sleep Deprivation Sleep Disorders
• ISSN:
  1556-407X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  455-468
• Volume:
  10
• Issue:
  4
• NIOSHTIC Number:
  nn:20052724
• Citation:
  Sleep Med Clin 2015 Dec; 10(4):455-468
• Contact Point Address:
  Kristen L. Knutson, PhD, Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 6076, Chicago, IL 60637, USA
• Email:
  kknutson@medicine.bsd.uchicago.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Chicago
• Peer Reviewed:
  False
• Start Date:
  20090901
• Source Full Name:
  Sleep Medicine Clinics
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:024f4a5a81df91d557a316d875deb83de8c7036ef0730007148221fec1354e67882982375fd126fdef470eb5e7b7a09ee46eeb1c1246a57e83f80b71f2861946
• Download URL:
  https://stacks.cdc.gov/view/cdc/212204/cdc_212204_DS1.pdf
• File Type:
  [PDF - 259.52 KB ]