Later Chronotype Is Associated with Higher Hemoglobin A1c in Prediabetes Patients

Details

• Personal Author:
  Anothaisintawee T ; Knutson KL ; Lertrattananon D ; Reutrakul S ; Thakkinstian A ; Thamakaison S
• Description:
  The circadian system is known to play a role in glucose metabolism. Chronotype reflects the interindividual variability in the phase of entrainment. Those with later chronotype typically prefer later times in the day for different activities such as sleep or meals. Later chronotype has been shown to be associated with metabolic syndrome, increased diabetes risk and poorer glycemic control in type 2 diabetes patients. In addition, "social jetlag", a form of circadian misalignment due to a mismatch between social rhythms and the circadian clock, has been shown to be associated with insulin resistance. Other sleep disturbances (insufficient sleep, poor sleep quality and sleep apnea) have also been shown to affect glucose metabolism. In this study, we explored whether there was a relationship between chronotype, social jetlag and hemoglobin A1c (HbA1c) levels in prediabetes patients, independent of other sleep disturbances. A cross-sectional study was conducted at the Department of Family Medicine, Ramathibodi Hospital, Bangkok, from October 2014 to March 2016 in 1014 non-shift working adults with prediabetes. Mid-sleep time on free day adjusted for sleep debt (MSFsc) was used as an indicator of chronotype. Social jetlag was calculated based on the absolute difference between mid-sleep time on weekdays and weekends. The most recent HbA1c values and lipid levels were retrieved from clinical laboratory databases. Univariate analyses revealed that later MSFsc (p = 0.028) but not social jetlag (p = 0.48) was significantly associated with higher HbA1c levels. Multivariate linear regression analysis was applied to determine whether an independent association between MSFsc and HbA1c level existed. After adjusting for age, sex, alcohol use, body mass index (BMI), social jetlag, sleep duration, sleep quality and sleep apnea risk, later MSFsc was significantly associated with higher HbA1c level (B = 0.019, 95% CI: 0.00001, 0.038, p = 0.049). The effect size of one hour later MSFsc on HbA1c (standardized coefficient = 0.065) was approximately 74% of that of the effect of one unit (kg/m2) increase in BMI (standardized coefficient = 0.087). In summary, later chronotype is associated with higher HbA1c levels in patients with prediabetes, independent of social jetlag and other sleep disturbances. Further research regarding the potential role of chronotype in diabetes prevention should be explored. [Description provided by NIOSH]
• Subjects:
  Circadian Rhythm Energy Metabolism Occupational Health Risk Assessment Risk Factors Safety Sleep Sleep Initiation And Maintenance Disorders
• Keywords:
  Author Keywords: Chronotype BMI Body Mass Index Circadian Rhythm Circadian Rhythms Genetic Factors Hemoglobin A1c Hormone Activity Metabolic Effects Prediabetes Risk Factors Sleep Sleep Deprivation Sleep Disorders Sociological Factors Weight Factors

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• ISSN:
  0742-0528
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  393-402
• Volume:
  34
• Issue:
  3
• NIOSHTIC Number:
  nn:20052691
• Citation:
  Chronobiol Int 2017 Sep; 34(3):393-402
• Contact Point Address:
  Sirimon Reutrakul, CDE, Division of Endocrinology and Metabolism, Department of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Rd, Ratchathewi, Bangkok 10400, Thailand
• Email:
  sreutrak10800@gmail.com
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Chicago
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Chronobiology International
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f59d3b9394e3118dc9f65ca425de3e9fee21381247489069e26f5eaadfdfa43483fb0444cfc705826f49050f1f8b984e777225efad90acb8853326ad7d9022bb
• Download URL:
  https://stacks.cdc.gov/view/cdc/212187/cdc_212187_DS1.pdf
• File Type:
  [PDF - 1.12 MB ]