Association Between Sleep Timing, Obesity, Diabetes: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Cohort Study

Details

• Personal Author:
  Cai J ; Daviglus ML ; Gallo LC ; Knutson KL ; Loredo JS ; Mossavar-Rahmani Y ; Patel SR ; Ramos AR ; Redline S ; Teng Y ; Wu D ; Zee PC
• Description:
  Study Objectives: Recent studies implicate inadequate sleep duration and quality in metabolic disease. Fewer studies have examined the timing of sleep, which may be important because of its potential impact on circadian rhythms of metabolic function. We examined the association between sleep timing and metabolic risk among Hispanic/Latino adults. Methods: Cross-sectional data from community-based study of 13429 participants aged 18-74 years. People taking diabetic medications were excluded. Sleep timing was determined from self-reported bedtimes and wake times. Chronotype was defined as the midpoint of sleep on weekends adjusted for sleep duration on weekdays. Other measurements included body mass index (BMI), fasting glucose levels, estimated insulin resistance (HOMA-IR), glucose levels 2 hours post oral glucose ingestion, and hemoglobin A1c. Survey linear regression models tested associations between sleep timing and metabolic measures. Analyses were stratified by diabetes status and age-group when significant interactions were observed. Results: Among participants with diabetes, fasting glucose levels were positively associated with bedtime (approximately +3%/hour later, p < .01) and midpoint of sleep (approximately +2%/hour later, p < .05). In participants with and without diabetes combined, HOMA-IR was positively associated with midpoint of sleep (+1.5%/hr later, p < .05), and chronotype (+1.2%/hour later, p < .05). Associations differed by age-group. Among those < 36 years, later sleep timing was associated with lower BMI, lower fasting glucose, and lower HbA1c, but the opposite association was observed among older participants. Conclusions: Later sleep timing was associated with higher estimated insulin resistance across all groups. Some associations between sleep timing and metabolic measures may be age-dependent. [Description provided by NIOSH]
• Subjects:
  Age Factors Circadian Rhythm Energy Metabolism Occupational Health Safety Sleep Sleep Initiation And Maintenance Disorders
• Keywords:
  Age Factors Author Keywords: Sleep Timing BMI Body Mass Index Circadian Circadian Rhythms Diabetes Genetic Factors Hormone Activity Insulin Resistance Metabolic Effects Sleep Deprivation Sleep Disorders Sociological Factors

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• ISSN:
  0161-8105
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Florida ; Illinois ; Massachusetts ; New York ; North Carolina ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  40
• Issue:
  4
• NIOSHTIC Number:
  nn:20052693
• Citation:
  Sleep 2017 Apr; 40(4):zsx014
• Contact Point Address:
  Kristen L. Knutson, PhD, Department of Neurology, Center for Sleep and Circadian Medicine, Northwestern University Feinberg School of Medicine, 710 N Lakeshore Drive, Room 523, Chicago, IL 60611, USA
• Email:
  kristen.knutson@northwestern.edu
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Chicago
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Sleep
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6f4b3f1ed6850577095640170f55755acd5b84d942bf34f942069f7589afbe1786f4b5649330fd6f366919750f9bf2bef78f5e2115b5bdd91254d2ab971333da
• Download URL:
  https://stacks.cdc.gov/view/cdc/212189/cdc_212189_DS1.pdf
• File Type:
  [PDF - 151.38 KB ]