Antigen Profiling of Field Metalworking Fluids

Details

• Personal Author:
  Chandra H ; Lam YW ; Yadav JS
• Description:
  This project is summarized in the following list: Isolated a novel strain of M. immunogenum MJY27 from In use MWFs; First report of identification of MI antigens directly from the MWFs; Identified a total of 72 MI specific antigens from the used MWFs; Among the abundant antigens 14 antigens were found to be T cell antigens; Eight antigens among the T cells antigens were found to be metal binders; We have functionally validated Ag D for T cell response in mice and in human DC-T cell assay. In conclusion Identified Ags may provide a key to understanding the etiological aspects of the occupational HP disease development and facilitate development of immunodiagnostic and intervention strategies for HP patients in occupational settings. [Description provided by NIOSH]
• Subjects:
  Antigens Immune System Lung Diseases Manufacturing And Industrial Facilities Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Cell Biology Cellular Effects Hypersensitivity Pneumonitis Immune Reaction Immunodiagnosis Lung Disease Machinists Metalworking Fluids MWFs Mycobacterium
• Publisher:
  University of Cincinnati
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 1 ; OSHA Region 5 ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-19
• NIOSHTIC Number:
  nn:20052392
• Citation:
  17th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 13-14, 2016, Cincinnati, Ohio. Cincinnati, OH: University of Cincinnati, 2016 Oct; :1-19
• Email:
  chandrhh@ucmail.uc.edu
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  17th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 13-14, 2016, Cincinnati, Ohio
• End Date:
  20170731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b64befe466f0abfae0afe631d8128d590178935f57bfc38b6434918c583b631c5c48a4c0d90f2d49ee4a4b7d5be5a8470c502debf3d259f3fda9db8629011ed2
• Download URL:
  https://stacks.cdc.gov/view/cdc/211923/cdc_211923_DS1.pdf
• File Type:
  [PDF - 4.54 MB ]