Hair Manganese as an Exposure Biomarker Among Welders

Details

• Personal Author:
  Baker MG ; Reiss B ; Seixas, Noah S. ; Sheppard L ; Simpson CD ; Stover B
• Description:
  Quantifying exposure and dose to manganese (Mn) containing airborne particles in welding fume presents many challenges. Common biological markers such as Mn in blood or Mn in urine have not proven to be practical biomarkers even in studies where positive associations were observed. However, hair Mn (MnH) as a biomarker has the advantage over blood and urine that it is less influenced by short-term variability of Mn exposure levels because of its slow growth rate. The objective of this study was to determine whether hair can be used as a biomarker for welders exposed to manganese. Hair samples (1cm) were collected from 47 welding school students and individual air Mn (MnA) exposures were measured for each subject. MnA levels for all days were estimated with a linear mixed model using welding type as a predictor. A 30-day time-weighted average MnA (MnA30d) exposure level was calculated for each hair sample. The association between MnH and MnA30d levels was then assessed. A linear relationship was observed between log-transformed MnA30d and log-transformed MnH. Doubling MnA30d exposure levels yields a 20% (95% confidence interval: 11-29%) increase in MnH. The association was similar for hair washed following two different wash procedures designed to remove external contamination. Hair shows promise as a biomarker for inhaled Mn exposure given the presence of a significant linear association between MnH and MnA30d levels. [Description provided by NIOSH]
• Subjects:
  Air Pollution Biomarkers Environmental Exposure Manganese Occupational Exposure Occupational Health Respiratory System Safety Welding
• Keywords:
  Air Quality Measurement Analytical Models Author Keywords: Biomarker Of Exposure Breathing Zone Employee Exposure Exposure Assessment Exposure Levels Exposure Science Hair Hair Analysis Inhalation Manganese Compounds And Fume Models Sampling Time Weighted Average Exposure Welders Welding Welding Fumes

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• ISSN:
  0003-4878
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  139-149
• Volume:
  60
• Issue:
  2
• NIOSHTIC Number:
  nn:20051307
• Citation:
  Ann Occup Hyg 2016 Mar; 60(2):139-149
• Contact Point Address:
  Boris Reiss, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
• Email:
  reissb@uw.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Annals of Occupational Hygiene
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:747535a6f97c8227021e4a5e7d2a22c292231059542e41b3f4749645c9d42629ec2a45d3d6ad3be4f15f0355be31fa215cfb3e1ce7930dbb96188b97a0462d2d
• Download URL:
  https://stacks.cdc.gov/view/cdc/211343/cdc_211343_DS1.pdf
• File Type:
  [PDF - 1.42 MB ]