Using Exposure Windows to Explore an Elusive Biomarker: Blood Manganese

Details

• Personal Author:
  Baker MG ; Seixas, Noah S. ; Sheppard L ; Simpson CD ; Stover B
• Description:
  Purpose: We sought to understand the time course between exposure to manganese (Mn) and uptake into the blood, to allow a more meaningful interpretation of exposure biomarker data, and to determine the utility of blood as a biomarker of Mn exposure. Methods: Welder trainees were monitored over the course of a five-quarter training program. Each quarter, trainees gave eight blood samples and had personal air monitoring four times. A mixed model was fit to obtain estimates of airborne exposure by welding type (fixed effect), adjusted for subject (random effect). Considering weekends and days absent as zero exposure, estimated exposures were summed over various exposure windows and related to measured blood manganese (MnB) using a mixed model. Results: A relationship consistent with zero was found between MnB and modeled 1 or 7 days of exposure. After 30 days of preceding exposure, a 1 mg-days/m(3) increase in air Mn is associated with a 0.57 ng/mL increase in MnB (95% CI -0.04, 1.19). Considering a 90-day exposure window and a cumulative exposure window, a 1 mg-days/m(3) increase in air Mn is associated with a 0.26 (95% CI 0.005, 0.51) and 0.09 (95% CI 0.006, 0.17) ng/mL increase in MnB, respectively. Conclusions: From this analysis, MnB may begin to act as a biomarker of Mn exposure over longer time periods, or at higher levels of exposure. This novel study design allowed investigation of how MnB relates to different time windows of exposure, representing the most robust Mn exposure assessment in the biomarker literature. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Environmental Exposure Environmental Monitoring Hematologic Tests Manganese Occupational Exposure Occupational Health Safety Welding
• Keywords:
  Air Monitoring Analytical Models Author Keywords: Manganese Biomarker Of Exposure Blood Samples Blood Stream Breathing Zone Employee Exposure Exposure Assessment Exposure Levels Exposure Modeling Exposure Windows Manganese Compounds And Fume Models Welders Welding Fumes

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• ISSN:
  0340-0131
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  89
• Issue:
  4
• NIOSHTIC Number:
  nn:20051305
• Citation:
  Int Arch Occup Environ Health 2016 May; 89(4):679-687
• Contact Point Address:
  Marissa G. Baker, Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
• Email:
  bakermg@uw.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Archives of Occupational and Environmental Health
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f0504939ae982e8504cfd29f14af9b284f3a8dbb1260b2de8d4e7f6284194bb0c4aca4b8f59d0070a12c8a3d95b85a5cd1df52acd7f2e0412a3896bd72d2f83e
• Download URL:
  https://stacks.cdc.gov/view/cdc/211342/cdc_211342_DS1.pdf
• File Type:
  [PDF - 458.53 KB ]