Variance Components of Short-Term Biomarkers of Manganese Exposure in an Inception Cohort of Welding Trainees

Details

• Personal Author:
  Baker MG ; Cocker J ; Morton J ; Seixas, Noah S. ; Sheppard L ; Simpson CD ; Stover B
• Description:
  Various biomarkers of exposure have been explored as a way to quantitatively estimate an internal dose of manganese (Mn) exposure, but given the tight regulation of Mn in the body, inter-individual variability in baseline Mn levels, and variability in timing between exposure and uptake into various biological tissues, identification of a valuable and useful biomarker for Mn exposure has been elusive. Thus, a mixed model estimating variance components using restricted maximum likelihood was used to assess the within- and between-subject variance components in whole blood, plasma, and urine (MnB, MnP, and MnU, respectively) in a group of nine newly-exposed apprentice welders, on whom baseline and subsequent longitudinal samples were taken over a three month period. In MnB, the majority of variance was found to be between subjects (94%), while in MnP and MnU the majority of variance was found to be within subjects (79% and 99%, respectively), even when controlling for timing of sample. While blood seemed to exhibit a homeostatic control of Mn, plasma and urine, with the majority of the variance within subjects, did not. Results presented here demonstrate the importance of repeat measure or longitudinal study designs when assessing biomarkers of Mn, and the spurious associations that could result from cross-sectional analyses. [Description provided by NIOSH]
• Subjects:
  Biomarkers Manganese Occupational Health Safety Welding
• Keywords:
  Author Keywords: Welders Biological Effects Biomarkers Of Exposure Variability Welders Welding Fumes
• ISSN:
  0946-672X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  123-129
• Volume:
  29
• NIOSHTIC Number:
  nn:20054683
• Citation:
  J Trace Elem Med Biol 2015 Jan; 29:123-129
• Contact Point Address:
  Marissa G Baker, Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way, NE, Suite 100, Seattle, WA 98105, USA
• Email:
  bakermg@uw.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Trace Elements in Medicine and Biology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:62c0bd47ff5fc4622cd7fcd43903726cfcfde56d85c617d5ff0485ba77cf1ef81f479b77cce3e6f967259fe9712a9d340980b622c9832394ce15a3318118c33d
• Download URL:
  https://stacks.cdc.gov/view/cdc/217141/cdc_217141_DS1.pdf
• File Type:
  [PDF - 148.22 KB ]