Suprachiasmatic nucleus and circadian core temperature rhythm in the rat

Details

• Personal Author:
  Ernsberger P ; Halberg F ; Lubanovic W ; Pasley JN ; Powell EW ; Scheving LE
• Description:
  The role of the suprachiasmatic nucleus (SCN) in circadian core temperature rhythms was investigated in rats. Twenty six singly housed adult male inbred Fischer-rats were standardized to light from 0600 to 1800 hours, alternating with darkness. Food and water were freely available. Bilateral electrolytic lesioning of the SCN was carried out on some of the animals, while others were sham operated. A temperature sensor was implanted intraperitoneally. After 16 weeks of the 12:12 light/dark schedule, there was a 6 hour delay in the schedule; after 8 days, a continuous light schedule was imposed for 3 weeks. Rats were then killed, and brains were examined to identify the extent of the lesions. The least squares fit of certain trial periods was used to analyze the telemetered data obtained at 10 minute intervals from each rat for the first 9 days. In the SCN lesioned rats which sustained destruction of both SCN, a circadian population rhythm persisted. The amplitude of the circadian temperature rhythm was attenuated and the rhythm's acrophase advanced from mid dark to a time near the transition from light to darkness. Unilateral lesions of the SCN altered the circadian amplitude but not the phasing. [Description provided by NIOSH]
• Subjects:
  Circadian Rhythm Laboratories Nervous System Occupational Health Periodicity Safety
• Keywords:
  Author Keywords: Suprachiasmatic Nucleus Biological-rhythms Brain Chronobiology Circadian-rhythms Circadian Rhythm Laboratory-animals Lesion Neurotoxic-effects NIOSH-Grant NIOSH-Publication Rat Temperature

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• ISSN:
  0306-4565
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  189-196
• Volume:
  5
• Issue:
  4
• NIOSHTIC Number:
  nn:00185755
• Citation:
  J Therm Biol 1980 Oct; 5(4):189-196
• Contact Point Address:
  Anatomy University of Arkansas 4301 West Markham Little Rock, Ark 72201
• Federal Fiscal Year:
  1981
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  University of Arkansas Med Scis Ltl Rock, Little Rock, Arkansas
• Peer Reviewed:
  True
• Start Date:
  19791201
• Source Full Name:
  Journal of Thermal Biology
• End Date:
  19880301
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1c7fe85445f96347ec96caea1a088b800713406447036ecba7e55ef05f877fe984d552a379fd5b32a0eda9701c8d07c25afb7cb47a96feb0af1a2fb1a7ab8989
• Download URL:
  https://stacks.cdc.gov/view/cdc/205651/cdc_205651_DS1.pdf
• File Type:
  [PDF - 873.98 KB ]