Changes with Age Characterize Circadian Rhythm in Telemetered Core Temperature of Stroke-Prone Rats

Details

• Personal Author:
  Halberg E ; Halberg F ; Halberg J ; Regal P
• Description:
  Nine 20-to 26-year-old and ten 70-to 78-year-old diurnally active, nocturnally resting women in Würzburg, Federal Republic of Germany, gave blood at 0700, 1000, 1300, 1600, 1900, and 2200 for radioimmunoassay of aldosterone. Single and population-mean cosinors were applied. A multivariate analysis of circadian rhythm characteristics revealed effects of age on the amplitude (p = .003) but not the mesor of aldosterone in women (i.e., the age effect could only be detected at certain circadian times but not at others). No change with age was found for concomitantly sampled men. Statistically significant interactions among circadian time, age, and sex (p = .001) establish the adrenocorticopause in women and suggest that it may occur earlier in women than in men, in keeping with similar results on serum cortisol in the same subjects. This phenomenon awaits scrutiny from the viewpoint of its bearing on longevity and life quality. These results also indicate the importance of assessing chronobiological characteristics. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Animals Circadian Rhythm Occupational Health Safety
• Keywords:
  Age Factors Animal Studies Author Keywords: Telemetry Biological Rhythms Circadian Rhythms Core Temperature Rat Stroke Temperature Regulation
• ISSN:
  0022-1422
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  28-30
• Volume:
  36
• Issue:
  1
• NIOSHTIC Number:
  nn:20061186
• Citation:
  J Gerontol 1981 Jan; 36(1):28-30
• Federal Fiscal Year:
  1981
• Performing Organization:
  University of Minnesota of Minneapolis-St Paul, Minneapolis, Minnesota
• Peer Reviewed:
  True
• Start Date:
  19770801
• Source Full Name:
  Journal of Gerontology
• End Date:
  19860331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:29ce3d1ee78c6cae17e082509d97d9f8ba637659a06da684643ad8ce0fcd5822c15e41685c2fa01d7bd709a620ef85399d90e372986e900e8b7021bf5a40300d
• Download URL:
  https://stacks.cdc.gov/view/cdc/224806/cdc_224806_DS1.pdf
• File Type:
  [PDF - 603.78 KB ]