Interleukin 1 and its inhibition in an inflammatory reaction caused by Aspergillus umbrosus

Details

• Personal Author:
  Husman KR ; Kotimaa M ; Lewis, Daniel M. ; Manninen A ; Mull JC ; Olenchock, Stephen A. ; Sorenson WG ; Terho EO ; Whitmer M
• Description:
  Male Sprague-Dawley-rats were exposed to an antigen extract and antigen plus endotoxin in a study of the inhibition of interleukin-1 (IL-1) in an inflammatory reaction resulting from exposure to Aspergillus-umbrosus. Rats were exposed three times, 3 days apart to antigen extract at 100 microliter/100 grams body weight and endotoxin at 1 million endotoxin units/milliliter, or to antigen extract alone. Alveolar macrophages were obtained through lavage. Exposure to A-umbrosus increased IL-1 activity 12 times in alveolar macrophages in-vivo. Total cell counts showed that the exposure caused an inflammatory condition in the lungs because the number of macrophages in the lavage fluids of the exposed rats increased from could increase IL-1 activity more than exposure to A-umbrosus plus endotoxin. The authors conclude that A-umbrosus can cause an IL-1- mediated inflammatory reaction similar to endotoxin. A-umbrosus is one of the causative agents of hypersensitivity pneumonitis. The authors suggest that IL-1 may also be involved in the pathogenesis of hypersensitivity pneumonitis. [Description provided by NIOSH]
• Subjects:
  Bacteria Dust Fungi Hazardous Substances Laboratories Lung Occupational Health Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Alveolar-cells Bacterial-dusts In-vivo-studies Laboratory-animals Lung-cells NIOSH-Author Respiratory-hypersensitivity Respiratory-system-disorders Toxins
• ISSN:
  0355-3140
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  75-77
• Volume:
  18
• NIOSHTIC Number:
  nn:00209450
• Citation:
  Scand J Work Environ Health 1992 Jun; 18(Suppl 2):75-77
• Contact Point Address:
  Dr A Manninen, Kuopio Regional Institute of Occupational Health, PO Box 93, SF-70701 Kuopio, Finland
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  True
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• Supplement:
  2
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e25c3ea214c41e99bd71855d6d0db73bc9e5db53a9f1a97d3dde6fdb33c090ddcbab4e0b798e8d747476181a0beedd21e3b6bf782c1633e67ae5ed1c8fe924df
• Download URL:
  https://stacks.cdc.gov/view/cdc/204967/cdc_204967_DS1.pdf
• File Type:
  [PDF - 1.81 MB ]