Information profiles on potential occupational hazards: phthalates

Details

• Description:
  Information profiles were presented for the following phthalates deemed to be significant based on their annual production quantities: butyl-benzyl-phthalate (85687), diallyl-phthalate (131179), di-n-butyl-phthalate (84742), di-2-ethylhexyl-phthalate (117817), diethyl-phthalate (84662), diisodecyl-phthalate (26761400), diisononyl-phthalate (28553120), dimethyl-phthalate (131113), ditridecyl-phthalate (119062), and diundecyl-phthalate (3648202), N-hexyl-N-decyl-phthalate (25724587) and mixed dialkyl (C7 to C11) phthalates. In general the phthalates had a low order of acute toxicity. Histological damage to the lungs, liver and kidneys was associated with acute oral and/or intraperitoneal exposures to some of the compounds. Others have caused slight skin and eye irritation. Repeated oral exposure to many of the esters resulted in liver and/or kidney damage. Butyl-benzyl-phthalate and di-2- ethylhexyl-phthalate induced development of leukemia in rats and hepatocellular carcinomas in mice, respectively. Ingestion of di-n- butyl-phthalate in humans caused nausea, dizziness, photophobia, lacrimation and conjunctivitis. Patients receiving blood stored in polyvinyl-chloride bags that contained residual di-2-ethylhexyl- phthalate suffered a respiratory distress syndrome called shock lung. Neurological effects have been reported in workers exposed to a mixture of phthalate esters in production vapors. Epidemiological studies of di-2-ethylhexyl-phthalate showed no adverse health effects. [Description provided by NIOSH]
• Subjects:
  Adhesives Carcinogens Epidemiology Epoxy Resins Hazardous Substances Insecticides Occupational Exposure Occupational Health Plastics Safety Solvents

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• Keywords:
  Coatings Contract-210-79-0030 NIOSH-Contract Occupational-exposure Plasticizers Resins Toxic-effects
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-147
• NIOSHTIC Number:
  nn:00188272
• NTIS Accession Number:
  PB89-215818
• Citation:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 82-520, Second Draft 1982 Mar; :1-147
• CAS Registry Number:
  Butyl benzyl phthalate (CAS RN 85-68-7) ; Decyl hexyl phthalate (CAS RN 25724-58-7) ; Diallyl phthalate (CAS RN 131-17-9) ; Dibutyl phthalate (CAS RN 84-74-2) ; Diethyl phthalate (CAS RN 84-66-2) ; Diisodecyl phthalate (CAS RN 26761-40-0) ; Diisononyl phthalate (CAS RN 28553-12-0) ; Dimethyl phthalate (CAS RN 131-11-3) ; Dioctyl phthalate (CAS RN 117-81-7) ; Ditridecyl phthalate (CAS RN 119-06-2) ; Diundecyl phthalate (CAS RN 3648-20-2)
• Federal Fiscal Year:
  1982
• Peer Reviewed:
  False
• Source Full Name:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 82-520, Second Draft
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:351ea6fc05fc9aa3342bc40df8a0ad9cea11335d4cc7eadf500f6499032c7ccb5023a078730f93ab99c5fe3eb928d26ce20021d55ba0d6d9101a7da1fde872a6
• Download URL:
  https://stacks.cdc.gov/view/cdc/204947/cdc_204947_DS1.pdf
• File Type:
  [PDF - 4.17 MB ]