Information profiles on potential occupational hazards: organic anhydrides

Details

• Description:
  Information profiles were presented on the following organic anhydrides by virtue of their importance in the industrial community: acetic-anhydride (108247), butyric-anhydride (106310), citraconic-anhydride (616024), dodecenylsuccinic-anhydride (25377735), isobutyric-anhydride (97723), maleic-anhydride (108316), phthalic-anhydride (85449), propionic-anhydride (123626), pyromellitic-dianhydride (89327), succinic-anhydride (108305), tetrahydrophthalic-anhydride (85438), and trimellitic-anhydride (552307). The organic anhydrides appeared to be moderately toxic with median lethal dose levels for rats ranging from 697 to 2600mg/kg. The maleic, phthalic, acetic and trimellitic anhydrides appeared to be the most acutely toxic of the group discussed. All were irritants to the skin, eyes, and respiratory tract. Injection site tumors have occurred following administration of succinic and maleic anhydrides. Limited evidence suggested teratogenic potentials for acetic, maleic, phthalic, and succinic anhydrides. [Description provided by NIOSH]
• Subjects:
  Agriculture Carcinogens Epoxy Resins Hazardous Substances Metals Occupational Health Plastics Safety Teratogenesis
• Keywords:
  Agricultural-chemicals Contract-210-79-0030 Metal-finishing NIOSH-Contract Plasticizers Resins Teratogens Toxic-effects
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-126
• NIOSHTIC Number:
  nn:00188277
• NTIS Accession Number:
  PB89-216618
• Citation:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-635, Second Draft 1982 Feb; :1-126
• CAS Registry Number:
  1,2,3,6-Tetrahydrophthalic anhydride (CAS RN 85-43-8) ; Acetic anhydride (CAS RN 108-24-7) ; Butyric anhydride (CAS RN 106-31-0) ; Citraconic anhydride (CAS RN 616-02-4) ; Dodecenylsuccinic anhydride (CAS RN 25377-73-5) ; Isobutyric anhydride (CAS RN 97-72-3) ; Maleic anhydride (CAS RN 108-31-6) ; Phthalic anhydride (CAS RN 85-44-9) ; Propionic anhydride (CAS RN 123-62-6) ; Pyromellitic dianhydride (CAS RN 89-32-7) ; Succinic anhydride (CAS RN 108-30-5) ; Trimellitic anhydride (CAS RN 552-30-7)
• Federal Fiscal Year:
  1982
• Peer Reviewed:
  False
• Source Full Name:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-635, Second Draft
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:009d48e86c4621718fbbe141121ce5a4f86c3fc3d9da830b7124dd7d04dd21205f855fa16129baf05cf9ce8a983420cf1b2f17f7531110be11441031fce46df5
• Download URL:
  https://stacks.cdc.gov/view/cdc/204946/cdc_204946_DS1.pdf
• File Type:
  [PDF - 3.43 MB ]