Information profiles on potential occupational hazards: epoxy compounds (non-cyclic)

Details

• Description:
  Information profiles were presented for the following epoxy compounds deemed to be significant due to their commercial importance: n-alkyl-glycidyl-ethers, allyl-glycidyl-ether (106923), 1,2-butylene-oxide (106887), butyl-glycidyl-ether (2426086), 1,2- epoxy-hexadecane (7320378), ethylene-oxide (75218), 2-ethylhexyl- glycidyl-ether (2461156), glycidol (556525), glycidyl-acrylate (106901), glycidyl-methacrylate (106912), and propylene-oxide (75569). The median lethal toxicity value in rats for these compounds ranged from 232mg/kg for glycidyl-acrylate to 17100mg/kg for n-alkyl-glycidyl. Most of the compounds were mild to moderate skin and eye irritants. Ethylene-oxide was shown to be teratogenic in mice when given by intravenous injection, but not in rats exposed by inhalation. Several of these compounds demonstrated positive mutagenic responses. Butylene-oxide and glycidyl-methacrylate caused no increase in tumors after administered dermally and by gavage, respectively. Ethylene-oxide demonstrated a weak positive response in a carcinogenicity bioassay. A positive carcinogenic result was obtained for 1,2-epoxyhexadecane in a skin painting study. Propylene-oxide produced tumors at the site of injection following subcutaneous administration. [Description provided by NIOSH]
• Subjects:
  Adhesives Carcinogens Epoxy Resins Hazardous Substances Mutagens Occupational Exposure Occupational Health Safety Surface-Active Agents Teratogenesis
• Keywords:
  Contract-210-79-0030 Fumigants NIOSH-Contract Occupational-exposure Resins Surfactants Teratogens Toxic-effects
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-118
• NIOSHTIC Number:
  nn:00188271
• NTIS Accession Number:
  PB89-216634
• Citation:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-637, Second Draft 1982 Feb; :1-118
• CAS Registry Number:
  (±)-Propylene oxide (CAS RN 75-56-9) ; 1,2-Epoxybutane (CAS RN 106-88-7) ; 1,2-Epoxyhexadecane (CAS RN 7320-37-8) ; 2-Ethylhexyl glycidyl ether (CAS RN 2461-15-6) ; Allyl glycidyl ether (CAS RN 106-92-3) ; Butyl glycidyl ether (CAS RN 2426-08-6) ; Ethylene oxide (CAS RN 75-21-8) ; Glycidol (CAS RN 556-52-5) ; Glycidyl acrylate (CAS RN 106-90-1) ; Glycidyl methacrylate (CAS RN 106-91-2)
• Federal Fiscal Year:
  1982
• Peer Reviewed:
  False
• Source Full Name:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-637, Second Draft
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e2bc6ab286e24d2cbbd611aaabfbfc14b25f7a4781681473057f086047768329141da429748bae53783629b64e185778999969910736b8b191d188abc23666db
• Download URL:
  https://stacks.cdc.gov/view/cdc/204941/cdc_204941_DS1.pdf
• File Type:
  [PDF - 3.69 MB ]