Information profiles on potential occupational hazards: nitrophenols

Details

• Description:
  Information profiles were presented for the following nitrophenols deemed important in the industrial community: 2-nitrophenol (88755), 3-nitrophenol (554847), 4-nitrophenol (100027), 2,4- dinitrophenol (51285), and 2,4,6-trinitrophenol (88891). The mononitrophenols were moderately toxic to animals, causing initial stimulation and subsequent depression of the respiratory and central nervous systems. Positive results were obtained in several mutagenicity assays for 3-nitrophenol and 4-nitrophenol. 2,4- Dinitrophenol was far more acutely toxic than other important nitrophenol derivatives. It was able to uncouple oxidative phosphorylation by suppressing the coupling of electron flow to synthesis of adenosine-triphosphatase. It caused weakness, intense thirst and sweating, increased body temperature and respiration rate, neuritis, convulsions, and the rapid onset of rigor mortis after death. It has also caused cataracts in humans when used as a weight reducing aid. Inhalation of 2,4,6-trinitrophenol has caused considerable irritation to the eyes and to the mucous membrane of the respiratory tract. Dermal exposure has produced severe skin irritation and sensitization. [Description provided by NIOSH]
• Subjects:
  Explosions Explosive Agents Eye Foreign Bodies Fungi Fungicide, Industrial Hazardous Substances Mutagens Nitrogen Compounds Occupational Health Safety Skin

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• Keywords:
  Contract-210-79-0030 Explosives Eye-irritants Fungicides NIOSH-Contract Nitro-compounds Preservatives Skin-exposure Toxic-effects
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-75
• NIOSHTIC Number:
  nn:00188278
• NTIS Accession Number:
  PB89-215842
• Citation:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-536, Second Draft 1981 Apr; :1-75
• CAS Registry Number:
  2,4-Dinitrophenol (CAS RN 51-28-5) ; 2-Nitrophenol (CAS RN 88-75-5) ; 3-Nitrophenol (CAS RN 554-84-7) ; 4-Nitrophenol (CAS RN 100-02-7) ; Picric acid (CAS RN 88-89-1)
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  False
• Source Full Name:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-536, Second Draft
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:04bfdf6db87de801fbc4387a9cc937dc29c1c65571aecb56ca0bc767b5e258cc33886ef5a9a11301fe779421211bf2ae4178d590f5c0018345a73843a6ac2c62
• Download URL:
  https://stacks.cdc.gov/view/cdc/204945/cdc_204945_DS1.pdf
• File Type:
  [PDF - 1.75 MB ]