Information profiles on potential occupational hazards: thiourea and compounds

Details

• Description:
  Information profiles were presented for thiourea and the following thiourea compounds considered important in the industrial community: 1-allyl-3-(2-hydroxyethyl)-2-thiourea (105817), allylthiourea (109579), N,N'-bis(hydroxymethyl)thiourea (3084251), N,N'- bis(methoxymethyl)thiourea (51872265), 1-butyl-3-ethyl-2-thiourea (32900064), 1,3-dibutyl-2-thiourea (109466), 1,3-diisopropyl-2- thiourea (2986176), 1,3-dimethyl-2-thiourea (534134), N,N'-di-o- tolylthiourea (137973), 3-ethyl-1,1-dimethyl-2-thiourea (15361861), ethylthiourea (625536), (hydroxymethyl)thiourea (1000835), (2- methylphenyl)thiourea (614788), thiourea (62566), 1,3-diethyl-2- thiourea (105555), 1,3-diphenyl-2-thiourea (102089), ethylenethiourea (96457), 1-naphthylthiourea (86884), 1-phenyl-2- thiourea (103855), 1,1,3,3-tetramethylthiourea (2782914) and 1,1,3- trimethyl-2-thiourea (2489772). Most of the compounds were highly toxic to rodents. Positive mutagenic effects have been elicited in various assays with several of these compounds. The use of thiourea, diethylthiourea and tetramethylthiourea as antithyroid drugs indicated these compounds have antithyroidal effects in humans. Frequently observed side effects from the use of these medications have included headache, anxiety, fever, skin rash, and gastrointestinal disturbances. [Description provided by NIOSH]
• Subjects:
  Corrosion Flame Retardants Hazardous Substances Mutagens Occupational Health Safety
• Keywords:
  Bactericides Coatings Contract-210-79-0030 Corrosion-inhibitors Flame-retardants NIOSH-Contract Rodenticides Toxic-effects
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-124
• NIOSHTIC Number:
  nn:00188280
• NTIS Accession Number:
  PB89-215685
• Citation:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 82-500, Second Draft 1982 Jan; :1-124
• CAS Registry Number:
  (2-Methylphenyl)thiourea (CAS RN 614-78-8) ; 1-Allyl-3-(2-hydroxyethyl)-2-thiourea (CAS RN 105-81-7) ; Allylthiourea (CAS RN 109-57-9) ; Butylethylthiourea (CAS RN 32900-06-4) ; Diphenylthiourea (CAS RN 102-08-9) ; Ethylenethiourea (CAS RN 96-45-7) ; Ethylthiourea (CAS RN 625-53-6) ; N-(Hydroxymethyl)thiourea (CAS RN 1000-83-5) ; N,N′-Bis(1-methylethyl)thiourea (CAS RN 2986-17-6) ; N,N′-Bis(2-methylphenyl)thiourea (CAS RN 137-97-3) ; N,N′-Bis(hydroxymethyl)thiourea (CAS RN 3084-25-1) ; N,N′-Bis(methoxymethyl)thiourea (CAS RN 51872-26-5) ; N,N′-Dibutylthiourea (CAS RN 109-46-6) ; N,N′-Diethylthiourea (CAS RN 105-55-5) ; N,N′-Dimethylthiourea (CAS RN 534-13-4) ; N′-Ethyl-N,N-dimethylthiourea (CAS RN 15361-86-1 ; Phenylthiourea (CAS RN 103-85-5) ; Tetramethylthiourea (CAS RN 2782-91-4) ; Thiourea (CAS RN 62-56-6) ; Trimethylthiourea (CAS RN 2489-77-2) ; α-Naphthylthiourea (CAS RN 86-88-4)
• Federal Fiscal Year:
  1982
• Peer Reviewed:
  False
• Source Full Name:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 82-500, Second Draft
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a2c6bce7693bf1015021c064d0ef6dc94bb0549b6a1cdf848d7f1b47d1c50ea38d12dfd962e3833d38ca89846676d0bd82159df02ec361a400459ec1713277c5
• Download URL:
  https://stacks.cdc.gov/view/cdc/204948/cdc_204948_DS1.pdf
• File Type:
  [PDF - 3.45 MB ]