Information profiles on potential occupational hazards: chlorophenols

Details

• Description:
  Information profiles were presented on the following compounds: 2- chlorophenol (95578), 3-chlorophenol (108430), 4-chlorophenol (106489), 2,4-dichlorophenol (120832), 2,5-dichlorophenol (583788), 2,6-dichlorophenol (87650), 2,3,6-trichlorophenol (933755), 2,4,5- trichlorophenol (95954), 2,4,6-trichlorophenol (88062), 2,3,4,6- tetrachlorophenol (58902), and pentachlorophenol (87865). Studies have indicated that, administered in acute lethal doses, the chlorophenols produce excitation and increased respiration followed by motor weakness, hypotonia, convulsions, coma and death. All chlorophenols are well absorbed dermally, and toxic to skin and eyes. Workers exposed to 4-chlorophenol have demonstrated signs of functional disorders of the central and peripheral nervous systems and mucous membrane structure. Tumor development has been promoted in mice exposed to 2,4-dichlorophenol which was nonmutagenic in the Ames assay and produced abnormal fetuses in mice. 2,4,5- Trichlorophenol has caused liver and kidney damage, has promoted the development of papillomas when applied dermally to mice, and is an irritant to the eyes, skin, nose and throat of humans. 2,4,6- Trichlorophenol administered orally has increased the incidence of lymphomas and leukemia in male rats and leukocytosis and monocytosis in rats. Testing in mice has produced increased incidences of hepatocellular carcinomas, adenomas, hepatomas, and reticulum cell sarcomas. Studies of 2,3,4,6-tetrachlorophenol have shown no carcinogenic potentials, mutagenic activity, or teratogenicity of the compound; there were signs of fetotoxicity in rats. Description provided by NIOSH
• Subjects:
  • Carcinogens
  • Coloring Agents
  • Disinfectants
  • Epoxy Resins
  • Fungi
  • Fungicide, Industrial
  • Herbicides
  • Hydrocarbons
  • Laboratories
  • Occupational Health
  More +
• Keywords:
  • NIOSH-Contract
  • Contract-210-79-0030
  • Chlorinated-hydrocarbons
  • Preservatives
  • Laboratory-animals
  • Carcinogens
  • Resins
  • Pigments
  • Disinfectants
  • Herbicides
  More +
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-138
• NIOSHTIC Number:
  nn:00188264
• NTIS Accession Number:
  PB89-216220
• Citation:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-532, Second Draft 1981 Mar; :1-138
• CAS Registry Number:
  • 2,3,4,6-Tetrachlorophenol (CAS RN 58-90-2)
  • 2,3,6-Trichlorophenol (CAS RN 933-75-5)
  • 2,4,5-Trichlorophenol (CAS RN 95-95-4)
  • 2,4,6-Trichlorophenol (CAS RN 88-06-2)
  • 2,4-Dichlorophenol (CAS RN 120-83-2)
  • 2,5-Dichlorophenol (CAS RN 583-78-8)
  • 2,6-Dichlorophenol (CAS RN 87-65-0)
  • 2-Chlorophenol (CAS RN 95-57-8)
  • 3-Chlorophenol (CAS RN 108-43-0)
  • 4-Chlorophenol (CAS RN 106-48-9)
  More +
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  False
• Source Full Name:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-532, Second Draft
• Download URL:
  https://stacks.cdc.gov/view/cdc/204939/cdc_204939_DS1.pdf
• File Type:
  [PDF - 5.00 MB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6dabee324729a412d675ec8f73eaef4af07b7a1bac4fa1f43d93cabd7134817b25b8f8bbe02086cdf6037c7954eefea82f97c90ccce926e7db7f189f70429069