Information Profiles on Potential Occupational Hazards: Aminoazobenzenes

Details

• Description:
  Information profiles were prepared for the following aminoazobenzenes deemed to be of significance due to the fact that they each had an annual production volume in the range of at least the thousands of pounds: 4-aminoazobenzene (60093), 4- aminoazobenzene-3,4'-disulfonic-acid (101508), 4-aminoazobenzene- 3,4'-disulfonic-acid-disodium-salt (2706287), 4-aminoazobenzene- hydrochloride (3457985), 4'-aminoazobenzene-4-sulfonic-acid (104234), 4'-aminoazobenzene-4-sulfonic-acid-sodium-salt (2491716), ortho-aminoazotoluene (97563), ortho-aminoazotoluene-hydrochloride (2298137), C-I-Disperse-Orange-3 (730405), C-I-Disperse-Red-1 (2872528), C-I-Disperse-Red-5 (3769571), C-I-Disperse-Red-17 (3179893), C-I-Disperse-Yellow-3 (2832408), chrysoidine (532821), 2,4-diaminoazobenzene (495545), and N,N,-diethylaminoazobenzene (2481949). Information suggested that these compounds were only mildly toxic following acute exposure. Organ damage was noted in the liver, kidneys, and spleen following subchronic or chronic exposure to N,N-diethylaminoazobenzene, 4-aminoazobenzene, and ortho- aminoazotoluene. After metabolic activation in the Ames assay, positive findings were obtained for 4-aminoazobenzene, chrysoidine and ortho-aminoazotoluene. Cell transformation assays gave positive results for 4-aminoazobenzene and 4-aminoazobenzene-4-sulfonic-acid. Aminoazobenzenes, 4-aminoazobenzenes, chrysoidine and ortho- aminoazotoluene have tested positively in carcinogenicity studies using laboratory mice. Ortho-aminoazotoluene crossed the placenta and increased tumor incidence in the F1 generation. [Description provided by NIOSH]
• Subjects:
  Carcinogens Coloring Agents Disinfectants Hazardous Substances Ink Mutagens Occupational Health Polystyrenes Printing Safety Styrene

  More +
• Keywords:
  Azo-compounds Contract-210-79-0030 NIOSH-Contract Printing-inks Styrene-resins Toxic-effects
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-109
• NIOSHTIC Number:
  nn:00188285
• NTIS Accession Number:
  PB89-215826
• Citation:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-614, Second Draft 1981 Nov; :1-109
• CAS Registry Number:
  2,2′-[[4-[2-(2-Chloro-4-nitrophenyl)diazenyl]-3-methylphenyl]imino]bis[ethanol] (CAS RN 3769-57-1) ; 2,4-Diaminoazobenzene (CAS RN 495-54-5) ; 4-Amino-4′-nitroazobenzene (CAS RN 730-40-5) ; 4-Aminoazobenzene (CAS RN 60-09-3) ; 4-Aminoazobenzene-3,4′-disulfonic acid (CAS RN 101-50-8) ; 4-Aminoazobenzene-4′-sulfonic acid (CAS RN 104-23-4) ; Acid Yellow 9 (CAS RN 2706-28-7) ; Benzenamine, 2-methyl-4-[2-(2-methylphenyl)diazenyl]-, hydrochloride (1:1) (CAS RN 2298-13-7) ; Benzenamine, 4-(2-phenyldiazenyl)-, hydrochloride (1:1) (CAS RN 3457-98-5) ; Benzenesulfonic acid, 4-[2-(4-aminophenyl)diazenyl]-, sodium salt (1:1) (CAS RN 2491-71-6) ; Chrysoidine (CAS RN 532-82-1) ; Disperse Red 1 (CAS RN 2872-52-8) ; Disperse Red 17 (CAS RN 3179-89-3) ; Disperse Yellow 3 (CAS RN 2832-40-8) ; o-Aminoazotoluene (CAS RN 97-56-3) ; Solvent Yellow 56 (CAS RN 2481-94-9)
• Federal Fiscal Year:
  1982
• Peer Reviewed:
  False
• Source Full Name:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-614, Second Draft
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:df322b474f70f5553cab197b2ab2ba15c56e84b88ad07101ccc9ea9e51fafee1728aca85005b740849a1f306931bbc1ecdbd2a2eb012cdc9787b8894167c4e0a
• Download URL:
  https://stacks.cdc.gov/view/cdc/204938/cdc_204938_DS1.pdf
• File Type:
  [PDF - 2.90 MB ]