Alcohol, aldehydes, adducts and airways

Details

• Personal Author:
  Sapkota M ; Wyatt TA
• Description:
  Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins and DNA. Acetaldehyde and malondialdehyde are the major aldehydes generated in high levels in the lung of subjects with alcohol use disorder who smoke cigarettes. In addition to the above aldehydes, several other aldehydes like 4-hydroxynonenal, formaldehyde and acrolein are also detected in the lung due to exposure to toxic gases, vapors and chemicals. These aldehydes react with nucleophilic targets in cells such as DNA, lipids and proteins to form both stable and unstable adducts. This adduction may disturb cellular functions as well as damage proteins, nucleic acids and lipids. Among several adducts formed in the lung, malondialdehyde DNA (MDA-DNA) adduct and hybrid malondialdehyde-acetaldehyde (MAA) protein adducts have been shown to initiate several pathological conditions in the lung. MDA-DNA adducts are pre-mutagenic in mammalian cells and induce frame shift and base-pair substitution mutations, whereas MAA protein adducts have been shown to induce inflammation and inhibit wound healing. This review provides an insight into different reactive aldehyde adducts and their role in the pathogenesis of lung disease. [Description provided by NIOSH]
• Subjects:
  Aldehydes Formaldehyde Lipids Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety Smokers Tobacco Products
• Keywords:
  Acetaldehydes Adducts Airway-obstruction Airway-resistance Alcohol Alcohols Author Keywords: Lipid Peroxidation Cigarette-smoking Cigarette Smoke DNA-adducts Lung Lung-irritants Proteins Reactive Oxygen Species Respiratory-system-disorders

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• ISSN:
  2218-273X
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  5
• Issue:
  4
• NIOSHTIC Number:
  nn:20047345
• Citation:
  Biomolecules 2015 Dec; 5(4):2987-3008
• Contact Point Address:
  Todd A. Wyatt, Department of Environmental, Agricultural & Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA
• Email:
  twyatt@unmc.edu
• CAS Registry Number:
  Acetaldehyde (CAS RN 75-07-0) ; Malonaldehyde (CAS RN 542-78-9)
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Biomolecules
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e7293c3705dc02069b7d2a42e29c8edd430d49890e445b27f7851d5f60e7f5ce14f28bb11164b193ab08bc0ceaf476bd98f4b9a31df32797c941a56fe5eee7a5
• Download URL:
  https://stacks.cdc.gov/view/cdc/202450/cdc_202450_DS1.pdf
• File Type:
  [PDF - 765.47 KB ]