Multilayer paper-based device for colorimetric and electrochemical quantification of metals

Details

• Personal Author:
  Cate D ; Chailapakul O ; Dungchai W ; Henry CS ; Rattanarat P ; Volckens J
• Description:
  The release of metals and metal-containing compounds into the environment is a growing concern in developed and developing countries, as human exposure to metals is associated with adverse health effects in virtually every organ system. Unfortunately, quantifying metals in the environment is expensive; analysis costs using certified laboratories typically exceed $100/sample, making the routine analysis of toxic metals cost-prohibitive for applications such as occupational exposure or environmental protection. Here, we report on a simple, inexpensive technology with the potential to render toxic metals detection accessible for both the developing and developed world that combines colorimetric and electrochemical microfluidic paper-based analytical devices (mPAD) in a three-dimensional configuration. Unlike previous mPADs designed for measuring metals, the device reported here separates colorimetric detection on one layer from electrochemical detection on a different layer. Separate detection layers allows different chemistries to be applied to a single sample on the same device. To demonstrate the effectiveness of this approach, colorimetric detection is shown for Ni, Fe, Cu, and Cr and electrochemical detection for Pb and Cd. Detection limits as low as 0.12 µg (Cr) were achieved on the colorimetric layer while detection limits as low as 0.25 ng (Cd and Pb) were achieved on the electrochemical layer. Selectivity for the target analytes was demonstrated for common interferences. As an example of the device utility, particulate metals collected on air sampling filters were analyzed. Levels measured with the mPAD matched known values for the certified reference samples of collected particulate matter. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Cadmium Chemistry Chemistry, Analytic Chromium Colorimetry Ferrous Compounds Hazardous Substances Lead Metals Nickel Occupational Health Particulate Matter Safety

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• Keywords:
  Airborne-particles Analytical-chemistry Analytical-instruments Analytical-processes Cadmium-compounds Chemical-agent-detectors Chemical-analysis Chemical-extraction Chemical-processing Chromium-compounds Colorimeters Copper-compounds Detectors Electrochemical-analysis Environmental-technology Equipment-reliability Iron-compounds Lead-compounds Metal-compounds Metallic-compounds Nickel-compounds Particulates Quantitative-analysis Sample-preparation Sampling Toxic-materials

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• ISSN:
  0003-2700
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  86
• Issue:
  7
• NIOSHTIC Number:
  nn:20046359
• Citation:
  Anal Chem 2014 Apr; 86(7):3555-3562
• Contact Point Address:
  John Volckens, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States
• Email:
  john.volckens@colostate.edu
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9) ; Chromium (CAS RN 7440-47-3) ; Copper (CAS RN 7440-50-8) ; Iron (CAS RN 7439-89-6) ; Lead (CAS RN 7439-92-1) ; Nickel (CAS RN 7440-02-0)
• Federal Fiscal Year:
  2014
• Performing Organization:
  Colorado State University - Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20110701
• Source Full Name:
  Analytical Chemistry
• End Date:
  20130630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d507df3be3ca0f421bcc4ae3fd8979de36dc71668885bcea6700c3c62f0c86d0dfe17dd84c8fae03241d18f7b5bcac0a32c323a35b0b4f597d98dfc7bddaf720
• Download URL:
  https://stacks.cdc.gov/view/cdc/201443/cdc_201443_DS1.pdf
• File Type:
  [PDF - 4.14 MB ]