Particle deposition in a cast of human tracheobronchial airways

Details

• Personal Author:
  Cheng Y-S ; Zhou Y ; Cheng Y-S ; Zhou Y
• Description:
  Regional particle deposition efficiency and deposition patterns were studied experimentally in a human airway replica made from an adult cadaver. The replica includes the oral cavity, pharynx, larynx, trachea, and four generations of bronchi. This study reports deposition results in the tracheobronchial (TB) region. Nine different sizes of monodispersed, polystyrene latex fluorescent particles in the size range of 0.93-30 um were delivered into the lung cast with the flow rates of 15, 30, and 60 l min.-1. Deposition in the TB region appeared to increase with the increasing flow rate and particle size. Comparison of deposition data obtained from physical casts showed agreement with results obtained from realistic airway replicas that included the larynx. Deposition data obtained from idealized airway models or replicas showed lower deposition efficiency. We also compared experimental data with theoretical models based on a simplified bend and bifurcation model. A deposition equation derived from these models was used in a lung dosimetry model for inhaled particles, and we demonstrated that there was general agreement with theoretical models. However, the agreement was not consistent over the large range of Stokes number. The deposition efficiency was found as a function of the Stokes number, bifurcation angle, and the diameters of parent and daughter tubes. An empirical model was developed for the particle deposition efficiency in the TB region based on the experimental data. This model, combined with the oral deposition model developed previously, can be used to predict the particle deposition for inertial effects with improved accuracy. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Movements Air Pollutants, Occupational Asbestos Computers Dust Environmental Monitoring Inhalation Exposure Inorganic Chemicals Irritants Lung Occupational Health Particulate Matter Respiratory System Risk Assessment Risk Factors Safety Software

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• Keywords:
  Aerosol-particles Air-flow Air-sampling Airborne-fibers Analytical-processes Asbestos-dust Asbestos-fibers Computer-models Computer-software Exposure-levels Fibrous-dusts Inhalants Models Particulates Respiratory-irritants Respiratory-rate Risk-factors

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• ISSN:
  0278-6826
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  New Mexico ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  492-500
• Volume:
  39
• Issue:
  6
• NIOSHTIC Number:
  nn:20044485
• Citation:
  Aerosol Sci Technol 2005 Jun; 39(6):492-500
• Contact Point Address:
  Yue Zhou, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA
• Email:
  yzhou@LRRI.org
• Federal Fiscal Year:
  2005
• Performing Organization:
  Lovelace Biomedical & Environmental Research, Albuquerque, New Mexico
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Aerosol Science and Technology
• End Date:
  20080831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:08cfd9cc4ca0da9a145a3739d0c39d3ca26c62fe340e14f5941f8fc34d2cbdac56c3c737fa089598356f6b6adb45e6aef9e906763a77a6e6c6194126dbd94855
• Download URL:
  https://stacks.cdc.gov/view/cdc/200175/cdc_200175_DS1.pdf
• File Type:
  [PDF - 232.94 KB ]