Deposition of fiber in a human airway replica

Details

• Personal Author:
  Cheng YS ; Su W-C
• Description:
  Fiber is a notorious occupational hazard. Exposures to airborne asbestos fiber in the workplace increase the incidence of lung cancer for asbestos workers. Due to the lack of experimental data, the nature of fiber deposition in the human airway is unclear. In this study, a set of experiments were carried out to investigate the effect of fiber dimension and fiber inertia on the deposition pattern in the human airway replica. The deposition study was conducted by delivering aerosolized carbon fibers into the replica at constant inspiratory flow rates of 15-60 l/min. The results showed that impaction is the dominant deposition mechanism in this study. Most of the high-inertia fibers deposited in the oropharynx and the carina ridges of the bifurcations in tracheobronchial airways. A series of fiber deposition patterns were obtained and the deposition efficiencies were acquired for certain regions in the human airway replica. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Movements Air Pollutants, Occupational Asbestos Computers Dust Environmental Monitoring Inhalation Exposure Inorganic Chemicals Irritants Occupational Health Particulate Matter Risk Assessment Risk Factors Safety Software

  More +
• Keywords:
  Aerosol-particles Air-flow Air-sampling Airborne-fibers Analytical-processes Asbestos-dust Asbestos-fibers Author Keywords: Fiber Computer-models Computer-software Deposition Fraction Exposure-levels Fibrous-dusts Human Airway Inhalants Models Oral-cavity Particulates Respiratory-irritants Risk-factors Simulation-methods

  More +
• ISSN:
  0021-8502
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New Mexico ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  37
• Issue:
  11
• NIOSHTIC Number:
  nn:20044484
• Citation:
  J Aerosol Sci 2006 Nov; 37(11):1429-1441
• Contact Point Address:
  Wei-Chung Su, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA
• Email:
  wsu@LRRI.org
• Federal Fiscal Year:
  2007
• Performing Organization:
  Lovelace Biomedical & Environmental Research, Albuquerque, New Mexico
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Journal of Aerosol Science
• End Date:
  20080831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3b78fdffbf41a1f32c8991e4af14f2f304492a38ba409720b7a5f366b71b6a224ef3ba10ec2b4b8b254c6bee6950c51fb02e5d05d57bdbad6ff5d75e9bd341de
• Download URL:
  https://stacks.cdc.gov/view/cdc/200174/cdc_200174_DS1.pdf
• File Type:
  [PDF - 403.35 KB ]