Fiber deposition pattern in two human respiratory tract replicas

Details

• Personal Author:
  Cheng YS ; Su W-C
• Description:
  This study consisted of a series of experiments to investigate the factors that might affect the fiber deposition pattern in the human respiratory tract. Carbon fibers with uniform diameter and polydispersed length were chosen as the test material. Two geometry-defined human respiratory tract replicas encompassing the oral cavity, oropharynx, larynx, trachea, and first few bifurcations of the tracheobronchial airways were used in this research. Deposition studies were conducted by delivering aerosolized carbon fibers into the replicas at constant inspiratory flow rates of 15, 43.5, and 60 L/min. The results showed that impaction is the dominant deposition mechanism for both replicas. Most of the fibers with high momentum deposited in the oral airway (oral cavity to larynx), and fibers with low momentum were found to pass through the entire replica easily. When comparing the results between the two replicas, fiber length, inspiratory flow rate, and the geometry of the oral airway were found to be factors that might affect the fiber deposition pattern in the human respiratory tract. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Movements Air Pollutants, Occupational Asbestos Computers Dust Environmental Monitoring Inhalation Exposure Inorganic Chemicals Irritants Occupational Health Particulate Matter Risk Assessment Risk Factors Safety Software

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• Keywords:
  Aerosol-particles Air-flow Air-sampling Airborne-fibers Analytical-processes Asbestos-dust Asbestos-fibers Computer-models Computer-software Exposure-levels Fibrous-dusts Inhalants Models Oral-cavity Particulates Respiratory-irritants Risk-factors Simulation-methods

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• ISSN:
  0895-8378
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New Mexico ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  10
• NIOSHTIC Number:
  nn:20044483
• Citation:
  Inhal Toxicol 2006 Sep; 18(10):749-760
• Contact Point Address:
  Wei-Chung Su, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA
• Email:
  wsu@LRRI.org
• Federal Fiscal Year:
  2006
• Performing Organization:
  Lovelace Biomedical & Environmental Research, Albuquerque, New Mexico
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Inhalation Toxicology
• End Date:
  20080831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d0f841cc19daa58686732d53464108a15ae653f1c16387ea27c87f7ca82a6d13c08bbb5e6672712b8517dfc5a9845aea5f7d5429373586ae74a9362b3944cd37
• Download URL:
  https://stacks.cdc.gov/view/cdc/200173/cdc_200173_DS1.pdf
• File Type:
  [PDF - 5.88 MB ]