Cytokine Polymorphisms in Silicosis and Other Pneumoconioses

Details

• Personal Author:
  Landsittel DP ; Luster MI ; Simeonova P ; Vallyathan V ; Yucesoy, Berran
• Description:
  Silicosis and coal workers' pneumoconiosis are complex multifactorial lung diseases whose etiopathogenesis are not well defined. It is generally accepted that fibrotic lung disorders are mediated by macrophage-derived cytokines and growth factors. There is evidence showing a crucial role for tumor necrosis factor-a (TNF-alpha) and interleukin-1 (IL-1) in inflammation caused by silica dust and in the transition from simple to progressive massive fibrosis. In this review we discuss genetic polymorphisms responsible for regulating the production of these proinflammatory cytokines and their role in modifying silicosis severity. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Coal Coal Mining Dust Growth Lung Lung Diseases Mining Occupational Health Particulate Matter Pneumoconiosis Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide Silicosis

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• Keywords:
  Author Keywords: Silicosis Coal-workers Coal-workers-pneumoconiosis Cytokines Dust-particles Dusts Growth-factors Lung-disease Lung-disorders Particulate-dust Particulates Polymorphism Pulmonary-system-disorders Respiratory-system-disorders Silica-dusts Silicates TNF-a

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• ISSN:
  0300-8177
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  219-224
• Volume:
  234
• Issue:
  1
• NIOSHTIC Number:
  nn:20022965
• Citation:
  Mol Cell Biochem 2002 May-Jun; 234-235(1-2):219-224
• Contact Point Address:
  M.I. Luster, Toxicology and Molecular Biology Branch, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  mluster@cdc.gov
• CAS Registry Number:
  Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  True
• Source Full Name:
  Molecular and Cellular Biochemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8a1e5eb83ebb05d47a64b6e0daa7210aa7c69c26a4d4820579a12d5e1279f28a573454b9341ab0ac45b0425f577347447ff52256098540b731103e1bce5832e9
• Download URL:
  https://stacks.cdc.gov/view/cdc/199567/cdc_199567_DS1.pdf
• File Type:
  [PDF - 62.18 KB ]