Proposed Criteria for Mixed-Dust Pneumoconiosis: Definition, Descriptions, and Guidelines for Pathologic Diagnosis and Clinical Correlation

Details

• Personal Author:
  Abraham JL ; Chiyotani K ; De Vuyst P ; Dumortier P ; Gibbs AR ; Green FH ; Honma K ; Hosoda Y ; Iwai K ; Kohyama N ; Ostiguy G ; Roggli VL ; Shida H ; Taguchi O ; Vallyathan V ; Williams WJ
• Description:
  We defined mixed-dust pneumoconiosis (MDP) pathologically as a pneumoconiosis showing dust macules or mixed-dust fibrotic nodules (MDF), with or without silicotic nodules (SN), in an individual with a history of exposure to mixed dust. We defined the latter arbitrarily as a mixture of crystalline silica and nonfibrous silicates. According to our definition of MDP, therefore, MDF should outnumber SN in the lung to make a pathologic diagnosis of MDP. In the absence of confirmation of exposure, mineralogic analyses can be used to support the pathologic diagnosis. The clinical diagnosis of MDP requires the exclusion of other well-defined pneumoconioses, including asbestosis, coal workers' pneumoconiosis, silicosis, hematite miners' pneumoconiosis, welders' pneumoconiosis, berylliosis, hard metal disease, silicate pneumoconiosis, diatomaceous earth pneumoconiosis, carborundum pneumoconiosis, and corundum pneumoconiosis. Typical occupations associated with the diagnosis of MDP include metal miners, quarry workers, foundry workers, pottery and ceramics workers, and stonemasons. Irregular opacities are the major radiographic findings in MDP (ILO 1980), in contrast to silicosis, in which small rounded opacities predominate. Clinical symptoms of MDP are nonspecific. MDP must be distinguished from a variety of nonoccupational interstitial pulmonary disorders. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Asbestos Coal Coal Mining Dust Inorganic Chemicals Lung Lung Diseases Mining Occupational Exposure Occupational Health Pathology Pneumoconiosis Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide Silicosis

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• Keywords:
  Asbestosis Author Keywords: Dust Coal-dust Coal-workers-pneumoconiosis Dusts Exposure-levels Lung-disorders Occupational-exposure Pulmonary-system-disorders Respiratory-system-disorders Silica Silica-dusts Silicates

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• ISSN:
  0046-8177
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  35
• Issue:
  12
• NIOSHTIC Number:
  nn:20025990
• Citation:
  Hum Pathol 2004 Dec; 35(12):1515-1523
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  True
• Source Full Name:
  Human Pathology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e035a40a8478d6da09ffb09ea5f3f0c7af9bc7a28a4bd492c4182d7221a4f21251497a3b35b0b4f70614e99022651017dffcf0343307c5086e5acd1f7ce68e21
• Download URL:
  https://stacks.cdc.gov/view/cdc/197138/cdc_197138_DS1.pdf
• File Type:
  [PDF - 1.09 MB ]