Random Sampling or ‘Random’ Model in Skin Flux Measurements? [Commentary on “Investigation of the Mechanism of Flux Across Human Skin In Vitro by Quantitative Structure Permeability Relationships”]

Details

• Personal Author:
  Brumbaugh K ; Demchuk, Eugene ; Frasch F ; Landsittel DP ; Poda GI ; Sharp DS
• Description:
  Transdermal therapy receives increasing attention as an attractive alternative to traditional drug delivery. Unfortunately the exact algorithm of transdermal permeation that could guide medicinal chemists towards delivery optimization at an early stage of the drug design process still remains to be decoded. This paper discusses some major hurdles on the way to full understanding of Quantitative Structure-Activity Relationships (QSAR) of skin permeation. From the statistical perspective, a recently published combined data set is found to be inappropriate with respect to the distribution of major molecular descriptors, and therefore should be approached cautiously as a source for QSAR model training and in modelling of occupational and environmental skin exposures. [Description provided by NIOSH]
• Subjects:
  Drug Therapy Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Transdermal Drug Delivery Chemical Diversity Drug-therapy Drugs Human Skin Mathematical-models Quantitative Structure-activity Relationships Quantitative Structure-permeability Relationships Skin-absorption Skin-exposure Skin-tests Statistical-analysis

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• ISSN:
  0928-0987
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  197-200
• Volume:
  14
• Issue:
  3
• NIOSHTIC Number:
  nn:20021839
• Citation:
  Eur J Pharm Sci 2001 Oct; 14(3):197-200
• Contact Point Address:
  Eugene Demchuk, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA
• Email:
  eed@cdc.gov
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  Eur J Pharm Sci
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a6e43891fab923c72bef058e3c0d76a843c9654c3468412d723d751b1b3a6efbb1dbaef610c80c3e3810b955dead586072109195ae420ed4e09d951e138b6d4d
• Download URL:
  https://stacks.cdc.gov/view/cdc/198935/cdc_198935_DS1.pdf
• File Type:
  [PDF - 129.35 KB ]