Interpretation and prediction of the kinetics of transdermal drug delivery: oestradiol, hyoscine and timolol.

Details

• Personal Author:
  Guy RH ; Hadgraft J
• Description:
  A kinetic model for the prediction of the plasma concentration of topically administered drugs was described for estradiol, hyoscine, and timolol. The model was based on the physiochemical determination of the rate constants for the drugs between the transdermal device and the stratum corneum, the stratum corneum and viable tissue, the tissue capillary interface, and the excretion rate from blood to urine. Factors affecting the kinetics included competition for the drug at the device stratum corneum interface, the drug molecular weight, drug partition coefficients, and drug biological half life. The predictive equations were applied to estradiol, hyoscine, and timolol using physiochemical and pharmacokinetic data obtained from the published literature, the surface areas of the transdermal devices used as the delivery system, and the in-vitro release characteristics of the drugs in either the patch adhesive or the topical vehicle used for administration of the therapeutic agent. The kinetic simulations were compared to published human in-vivo data with good agreement. The authors conclude that the kinetic model can be used to determine the feasibility of transdermal drug delivery for different compounds. [Description provided by NIOSH]
• Subjects:
  Dermatitis Drug Therapy Occupational Health Safety Skin Skin Absorption
• Keywords:
  Analytical-models Author Keywords: Transdermal Drug Delivery Biokinetics Drug-therapy Hyoscine Medical-treatment NIOSH-Grant NIOSH-Publication Oestradiol Pharmacodynamics Skin-absorption Timolol

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• ISSN:
  0378-5173
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  159-163
• Volume:
  32
• Issue:
  2
• NIOSHTIC Number:
  nn:00185558
• Citation:
  Int J Pharm 1986 Oct; 32(2-3):159-163
• Contact Point Address:
  J. Hadgraft, The Welsh School of Pharmacy, University of Wales Institute of Science and Technology, Cardiff CFl 3XF, Wales, U.K.
• Federal Fiscal Year:
  1987
• Performing Organization:
  University of California San Francisco, San Francisco, California
• Peer Reviewed:
  True
• Start Date:
  19840928
• Source Full Name:
  International Journal of Pharmaceutics
• End Date:
  19871231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4629cf37787d45029a37f843f5cc89adbe9cb3e7576c2be905761b5385eeb3038ba0e19faa5f074802cf5105148071551c248ffb17ddbf021d74836c84d9539b
• Download URL:
  https://stacks.cdc.gov/view/cdc/185708/cdc_185708_DS1.pdf
• File Type:
  [PDF - 532.94 KB ]