Role of Sensitization Routes in the Development of Type I Hypersensitivity to Natural Rubber Latex in Mice

Details

• Personal Author:
  Meade BJ ; Munson AE ; Woolhiser MR
• Description:
  These experiments suggest that mouse can serve as an acceptable test system to mimic human latex exposure as mice exposed to latex proteins subcutaneously, intranasally and topically all demonstrated specific IgE responses. The increase in latex specific IgE following topical application of latex proteins suggests that human dermal exposure to products such as latex gloves has the potential to contribute to latex sensitization. Although preliminary immunoblots from s.c. and topically exposed mice show similar profiles, a number of bands appear to be unique, thereby supporting the possibility that different routes of human exposure may lead to the varied allergen-specific IgE profiles observed in health care workers and spina bifida patients. these models will be beneficial ion testing intervention strategies designed to prevent NRL hypersensitivity. [Description provided by NIOSH]
• Subjects:
  Animals Dermatitis Health Personnel Hypersensitivity Laboratories Occupational Health Safety Skin Skin Diseases Workplace
• Keywords:
  Allergens Allergic-dermatitis Allergy Animal-studies Author Keywords: Latex Health-care-personnel IgE Laboratory-animals Mouse Occupational Health And Safety Sensitization Work-environment Work Environment

  More +
• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  139-141
• Volume:
  36
• NIOSHTIC Number:
  nn:20000856
• Citation:
  Am J Ind Med 1999 Sep; 36(S1):139-141
• Contact Point Address:
  Michael R. Woolhiser, National Institute for Occupational Safety and Health, 1095 Willowdale Road MS 2015, Morgantown, WV 26505
• Email:
  mow6@cdc.gov
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d9ef93a240eff7ea97df6da8d7a000a615a856a1288cac6189c4033fdf1a4a1eb8f7ef0ef7ded3d985b529c89c5c2d89a7c101d5df43d6c1a2b0bc10360149b3
• Download URL:
  https://stacks.cdc.gov/view/cdc/198225/cdc_198225_DS1.pdf
• File Type:
  [PDF - 75.14 KB ]