U.S. flag An official website of the United States government.
Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

i

Chemical Activation of Innate and Specific Immunity in Contact Dermatitis

Public Domain


Details

  • Personal Author:
  • Description:
    Recent reports have suggested that chemical-induced allergic contact dermatitis may not be a traditional type IV hypersensitivity, in part due to the dual irritant and antigenic properties of sensitizing chemicals. In order to investigate the contribution of these properties to the molecular and cellular mechanism underlying allergic contact dermatitis, we evaluated oxazolone-induced changes in cell populations and cytokine production in the dermis of transgenic mice with impaired innate immunity (the FcgammaR subunit knockout mouse), and absent specific immunity (the athymic mouse), and the appropriate B6,129F2 and C57BL/6 control mice. Oxazolone and croton oil were applied in a single sensitizing dose, or in sensitizing and challenge doses, and the dermal response was evaluated by immunohistochemistry. In the wild type mice, with or without sensitization to oxazolone or croton oil, we observed mixed Th1/Th2 cytokine production and both CD4+ and CD8+ T lymphocytes; however, the neutrophil was the predominant cell in the dermis, even 72 h after final chemical application. Athymic mice displayed a similar neutrophil response with moderate Th1/Th2 cytokine production, and FcgammaR subunit knockout mice exhibited very mild dermatitis when treated with either oxazolone or croton oil. These results provide support for the hypothesis that allergic contact dermatitis is not a classic delayed type hypersensitivity, demonstrate the importance of the interaction between the irritant and antigenic properties of sensitizing chemicals in the development of allergic contact dermatitis, and suggest that the irritant effect of chemicals may be mediated through the cutaneous innate immune system. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    0022-202X
  • Document Type:
    Text
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Division:
    HELD - Health Effects Laboratory Division
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    168-176
  • Volume:
    115
  • Issue:
    2
  • NIOSHTIC Number:
    nn:20020870
  • Citation:
    J Invest Dermatol 2000 Aug; 115(2):168-176
  • Contact Point Address:
    Dr. Sally S. Tinkle, CDC/NIOSH, 1095 Willowdale Road, MS 3014, Morgantown, WV 26505
  • Email:
    sft3@cdc.gov
  • Federal Fiscal Year:
    2000
  • Peer Reviewed:
    True
  • Source Full Name:
    Journal of Investigative Dermatology
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:168ee28a5fa0ea2617b90030db1e563e00dc6e9a9e9688d015197d75218d5d1738787e8e91565739b482b436b5c4e9a3403b5cdfb9f78c3abecf26239f9dde0b
  • Download URL:
  • File Type:
    Filetype[PDF - 1.36 MB ]
PREVIOUS
ON THIS PAGE
Details
CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
BACK TO TOP