Acute Lung Injury Induced by a Commercial Leather Conditioner

Details

• Personal Author:
  Barger M ; Castranova, Vincent ; Ducatman BS ; Dyke C ; Frazer DG ; Grote, Ardith A. ; Hubbs, Ann F. ; Ma JY ; Parker J ; Robinson VA ; Schwegler-Berry D ; Siegel, Paul D. ; Xiang J
• Description:
  The composition and toxicity of a commercial leather conditioner that was responsible for a nationwide outbreak of respiratory illness in 1992 were studied. The outbreak of respiratory illness occurred with the use of a new formulation of an existing leather spray product. The chemical characteristics of the original and new spray formulations were studied and their toxic effects were assessed following inhalation exposure of guinea-pigs and Sprague- Dawley-rats for 2 hours. Both the original and new formulations contained propane (74986) and C7 to C8 alkanes as the major solvent components. The new formulation also contained traces of 2- butoxyethanol (111762), isomers of dipropylene-glycol-methyl-ether (34590948), and additional C10 to C12 alkanes as well as altered fluorohydrocarbon constituents. Exposure to aerosol from the new formulation resulted in the death of 33% or more of the animals, induced tachypnea, increased the number of erythrocytes and alveolar macrophages in bronchoalveolar lavage fluid, and induced pulmonary lesions characterized by alveolar hemorrhage, edema, and necrosis of type-I cells. The authors conclude that these studies confirm the toxicity of the new leather conditioner formulation and provide potential candidates for specific etiologic agents. [Description provided by NIOSH]
• Subjects:
  Chemistry Fluorocarbons Hazardous Substances Laboratories Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Chemical-composition Inhalation-studies Laboratory-animals Leather-finishing Lung-disease NIOSH-Author Pulmonary-edema Toxic-effects
• ISSN:
  0041-008X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  37-46
• Volume:
  143
• Issue:
  1
• NIOSHTIC Number:
  nn:00237833
• Citation:
  Toxicol Appl Pharmacol 1997 Mar; 143(1):37-46
• CAS Registry Number:
  2-Butoxyethanol (CAS RN 111-76-2) ; Dipropylene glycol monomethyl ether (CAS RN 3454,4′-Bis(dimethylamino)benzophenone (CAS RN 90-94-8)) ; Propane (CAS RN 74-98-6)
• Federal Fiscal Year:
  1997
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a4ef48a874845fe82666a9a7331f93b1a7edce72eefb1d1b1ec49632dc892220b44dbcf894933746bf9ac634508ee5b7f155fc39b646e1e4a7a028ab5813af1b
• Download URL:
  https://stacks.cdc.gov/view/cdc/197896/cdc_197896_DS1.pdf
• File Type:
  [PDF - 882.68 KB ]