Immediately Dangerous to Life or Health (IDLH) Value Profile: Hexafluoroacetone (CAS No. 684-16-2)

Details

• Alternative Title:
  IDLH Immediately dangerous to life or health value profile
• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Dotson, G. Scott ; Maier, Andrew ; Parker, Ann ; Haber, Lynn T.
• Description:
  Among the acute lethality studies, the rat LC50 value of 900 ppm for a 30-minute exposure period [Borzelleca and Lester 1965] was chosen as the basis for the IDLH value for hexafluoroacetone since it was the lowest value among studies with the most appropriate exposure duration. A composite uncertainty factor of 100 was applied to account for extrapolation from a lethal concentration in animals, animal to human differences, human variability, and uncertainties in the database, including uncertainties about the potential for developmental toxicity from acute exposure, as well as the lack of data on female reproductive toxicity and functional measures of reproductive toxicity, resulting in an IDLH value for hexafluoroacetone of 9 ppm. It should be noted that the IDLH value for hexafluoroacetone differs by more than an order of magnitude from the AEGL-2 30-minute value, which is intended to represent an airborne concentration of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape [NAS 2001]. The AEGL-2 value for hexafluoroacetone is based on a NOAEL for developmental effects in rats [NAS 2012]. NIOSH based the IDLH value for hexafluoroacetone on lethality data from a rat study [Borzelleca and Lester 1965]. More precisely, the point of departure was a LC50 value of 900 ppm for a 30-minute exposure period. The use of differing studies and endpoints results in the order of magnitude difference between the AEGL-2 and IDLH value. [Description provided by NIOSH]
• Subjects:
  Animals Chemistry Environmental Exposure Fluorocarbons Hazardous Substances Irritants Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety

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• Keywords:
  Chemicals; Chemical properties; Chemical hazards; Chemical composition; Chemical reactions; Hazards; Exposure levels; Risk factors; Animals; Laboratory animals; IDLH; Immediately Dangerous to Life or Health; Irritants; Respiratory irritants; Respiratory system disorders; Pulmonary system; Pulmonary system disorders; Hexafluoroacetone; Hexafluoro compounds; Toxic effects
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2016-172, 2016 Sep; :1-10
• Series:
  NIOSH Numbered Publications
• Subseries:
  Immediately Dangerous to Life or Health (IDLH) Value Profile
• DOI:
  https://doi.org/10.26616/NIOSHPUB2016172
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Periodical
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  28 pdf pages
• NIOSHTIC Number:
  nn:20048755
• CAS Registry Number:
  Hexafluoroacetone (CAS RN 684-16-2)
• Federal Fiscal Year:
  2016
• Performing Organization:
  Toxicology Excellence for Risk Assessment
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5bb90288eacfe82cc99ad48938dcf218eb920780f8f25ba08d161602962829c538f056313979bbc0481a5378db9be158dd23990af354cb8be1d130aaf7dd1d7e
• Download URL:
  https://stacks.cdc.gov/view/cdc/41588/cdc_41588_DS1.pdf
• File Type:
  [PDF - 423.30 KB ]