Coronary artery disease and cancer mortality in a cohort of workers exposed to vinyl chloride, carbon disulfide, rotating shift work, and o-toluidine at a chemical manufacturing plant

Details

• Personal Author:
  Carreon T ; Hanley, Kevin W. ; Hein, Misty J. ; Ruder, Avima M. ; Viet SM
• Description:
  BACKGROUND: We updated through 2007 the mortality experience of 1,874 workers employed at a New York State chemical manufacturing plant between 1946 and 2006. METHODS: Reassessed exposures to vinyl chloride, carbon disulfide, and shift work and categories of o-toluidine exposure were based on year, department and job title. Standardized mortality ratios (SMR) compared mortality to that of the US population. Internal comparisons used directly standardized rate ratios. RESULTS: Hepatobiliary cancer mortality was elevated among workers ever exposed to vinyl chloride (SMR = 3.80, 95% confidence interval 1.89-6.80); directly standardized rates increased with increasing vinyl chloride exposure duration. No increase in non-Hodgkin lymphoma mortality was observed with vinyl chloride and shift work exposures. Internal comparisons showed increased coronary artery disease mortality among long-term workers exposed to carbon disulfide and shift work for 4 years or more. CONCLUSIONS: Excess coronary artery disease mortality confirms earlier results; further investigation is needed to understand risk factors. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Chlorine Liver Manufacturing And Industrial Facilities Mortality Neoplasms Occupational Health Safety Shift Work Schedule Sulfides Toluidines Vinyl Chloride

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• Keywords:
  Author Keywords: Cohort Mortality Biliary-system-disorders Cancer Carbon Disulfide Cardiac-function Cardiovascular-disease Cardiovascular-system-disease Chemical-industry-workers Chemical-manufacturing-industry Chemical Manufacturing Chlorides Coronary Artery Disease Hepatotoxins Liver-cancer Mortality-data Mortality-rates O-toluidine Shift-work Shift-workers Shift Work Vinyl Chloride

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  398-411
• Volume:
  57
• Issue:
  4
• NIOSHTIC Number:
  nn:20043726
• Citation:
  Am J Ind Med 2014 Apr; 57(4):398-411
• Contact Point Address:
  Dr.Tania Carreon, PhD, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, Mailstop R-5, Cincinnati, OH 45226
• CAS Registry Number:
  Carbon disulfide (CAS RN 75-15-0) ; o-Toluidine (CAS RN 95-53-4) ; Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  2014
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:29c4309013e43e7b4cc9a463b5a25a7c2afd2917ffccc72517042e3d7c478206b71d5ba3ff5a09264c6e10f58d5ff61f1e6536f4ed2ebd8abd0397f690186bdd
• Download URL:
  https://stacks.cdc.gov/view/cdc/195549/cdc_195549_DS1.pdf
• File Type:
  [PDF - 163.53 KB ]