Coronary Artery Disease and Cancer Mortality in a Cohort of Workers Exposed to Vinyl Chloride, Carbon Disulfide, Rotating Shift Work, and o-Toluidine at a Chemical Manufacturing Plant

Details

• Alternative Title:
  Am J Ind Med
• Personal Author:
  Carreón, Tania ; Hein, Misty J. ; Hanley, Kevin W. ; Viet, Susan M. ; Ruder, Avima M.
• Description:
  Background ; We updated through 2007 the mortality experience of 1,874 workers employed at a New York State chemical manufacturing plant between 1946 and 2006. ; Methods ; Reassessed exposures to vinyl chloride, carbon disulfide, and shift work and categories of o-toluidine exposure were based on year, department and job title. Standardized mortality ratios (SMR) compared mortality to that of the US population. Internal comparisons used directly standardized rate ratios. ; Results ; Hepatobiliary cancer mortality was elevated among workers ever exposed to vinyl chloride (SMR =3.80, 95% confidence interval 1.89–6.80); directly standardized rates increased with increasing vinyl chloride exposure duration. No increase in non-Hodgkin lymphoma mortality was observed with vinyl chloride and shift work exposures. Internal comparisons showed increased coronary artery disease mortality among long-term workers exposed to carbon disulfide and shift work for 4 years or more. ; Conclusions ; Excess coronary artery disease mortality confirms earlier results; further investigation is needed to understand risk factors.
• Subjects:
  • Adult
  • Aged
  • Aged, 80 and over
  • Biliary Tract Neoplasms
  • Carbon Disulfide
  • Chemical Industry
  • Cohort Studies
  • Coronary Artery Disease
  • Female
  • Humans
  More +
• Keywords:
  • cohort mortality
  • chemical manufacturing
  • vinyl chloride
  • carbon disulfide
  • o-toluidine
  • shift work
  • cancer
  • coronary artery disease
• Source:
  Am J Ind Med. 2014; 57(4):398-411
• Pubmed ID:
  24464642
• Pubmed Central ID:
  PMC4512282
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  57
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/32331/cdc_32331_DS1.pdf
• File Type:
  [PDF - 490.01 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eda8acdc1d89b470b51ff767adc45ac3360e82de7eaef6bb0b17ef402dc38523