Coronary Artery Disease and Cancer Mortality in a Cohort of Workers Exposed to Vinyl Chloride, Carbon Disulfide, Rotating Shift Work, and o-Toluidine at a Chemical Manufacturing Plant

Details

• Alternative Title:
  Am J Ind Med
• Personal Author:
  Carreón, Tania ; Hein, Misty J. ; Hanley, Kevin W. ; Viet, Susan M. ; Ruder, Avima M.
• Description:
  Background
  
  We updated through 2007 the mortality experience of 1,874 workers employed at a New York State chemical manufacturing plant between 1946 and 2006.
  
  Methods
  
  Reassessed exposures to vinyl chloride, carbon disulfide, and shift work and categories of o-toluidine exposure were based on year, department and job title. Standardized mortality ratios (SMR) compared mortality to that of the US population. Internal comparisons used directly standardized rate ratios.
  
  Results
  
  Hepatobiliary cancer mortality was elevated among workers ever exposed to vinyl chloride (SMR =3.80, 95% confidence interval 1.89–6.80); directly standardized rates increased with increasing vinyl chloride exposure duration. No increase in non-Hodgkin lymphoma mortality was observed with vinyl chloride and shift work exposures. Internal comparisons showed increased coronary artery disease mortality among long-term workers exposed to carbon disulfide and shift work for 4 years or more.
  
  Conclusions
  
  Excess coronary artery disease mortality confirms earlier results; further investigation is needed to understand risk factors.
• Subjects:
  • Adult
  • Aged
  • Aged, 80 and over
  • Biliary Tract Neoplasms
  • Carbon Disulfide
  • Chemical Industry
  • Cohort Studies
  • Coronary Artery Disease
  • Female
  • Humans
  More +
• Keywords:
  • cohort mortality
  • chemical manufacturing
  • vinyl chloride
  • carbon disulfide
  • o-toluidine
  • shift work
  • cancer
  • coronary artery disease
• Source:
  Am J Ind Med. 2014; 57(4):398-411
• Pubmed ID:
  24464642
• Pubmed Central ID:
  PMC4512282
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  57
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/32331/cdc_32331_DS1.pdf
• File Type:
  [PDF - 490.01 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eda8acdc1d89b470b51ff767adc45ac3360e82de7eaef6bb0b17ef402dc38523