Cardiovascular biomarkers predict susceptibility to lung injury in World Trade Center dust-exposed firefighters

Details

• Personal Author:
  Cho SJ ; Comfort AL ; Kwon S ; Naveed B ; Nolan A ; Prezant DJ ; Rom, William N. ; Weiden MD
• Description:
  Pulmonary vascular loss is an early feature of chronic obstructive pulmonary disease. Biomarkers of inflammation and of metabolic syndrome predict loss of lung function in World Trade Center (WTC) lung injury (LI). We investigated if other cardiovascular disease (CVD) biomarkers also predicted WTC-LI. This nested case-cohort study used 801 never-smoker, WTC-exposed firefighters with normal pre-9/11 lung function presenting for subspecialty pulmonary evaluation (SPE) before March 2008. A representative subcohort of 124 out of 801 subjects with serum drawn within 6 months of 9/11 defined CVD biomarker distribution. Post-9/11 forced expiratory volume in 1 s (FEV1) at defined cases were as follows: susceptible WTC-LI cases with FEV1 ≤77% predicted (66 out of 801) and resistant WTC-LI cases with FEV1 >/=107% predicted (68 out of 801). All models were adjusted for WTC exposure intensity, body mass index at SPE, age on 9/11 and pre-9/11 FEV1. Susceptible WTC-LI cases had higher levels of apolipoprotein-AII, C-reactive protein and macrophage inflammatory protein-4 with significant relative risks (RRs) of 3.85, 3.93 and 0.26, respectively, with an area under the curve (AUC) of 0.858. Resistant WTC-LI cases had significantly higher soluble vascular cell adhesion molecule and lower myeloperoxidase, with RRs of 2.24 and 2.89, respectively (AUC 0.830). Biomarkers of CVD in serum 6 months post-9/11 predicted either susceptibility or resistance to WTC-LI. These biomarkers may define pathways either producing or protecting subjects from pulmonary vascular disease and associated loss of lung function after an irritant exposure. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biomarkers Cardiovascular Diseases Cardiovascular System Dust Emergencies Emergency Responders Firefighters Immune System Lung Lung Diseases Occupational Health Particulate Matter Respiratory Function Tests Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety

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• Keywords:
  Airborne-dusts Airway-obstruction Author Keywords: Airway Inflammation Cardiovascular-system Cardiovascular-system-disease Cellular-reactions Cytokines Emergency-responders Emergency-response Fire-fighters Immune-reaction Lung-disorders Lung-function Particulate-dust Peroxidases Proteins Pulmonary-function Pulmonary-function-tests Pulmonary-system-disorders Pulmonary Function Testing Respiratory-system-disorders Risk-factors Serology

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• ISSN:
  0903-1936
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  41
• Issue:
  5
• NIOSHTIC Number:
  nn:20043099
• Citation:
  Eur Respir J 2013 May; 41(5):1023-1030
• Contact Point Address:
  A. Nolan, Division of Pulmonary, Critical Care and Sleep, New York University School of Medicine 550 1st Avenue, NB 7N24, New York, NY 10016, USA
• Email:
  anna.nolan@med.nyu.edu
• Federal Fiscal Year:
  2013
• Performing Organization:
  New York City Fire Department
• Peer Reviewed:
  True
• Start Date:
  20040701
• Source Full Name:
  European Respiratory Journal
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cb41820c178c8bfab12180c26db24b0391b8ec7dd2a5a93d1b4a456f346111147fc33ef8646d0d20ac0084f6f44b7edd50c54a7ed747bdba7fc3d57bfe32a7ec
• Download URL:
  https://stacks.cdc.gov/view/cdc/195113/cdc_195113_DS1.pdf
• File Type:
  [PDF - 212.55 KB ]