Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study

Details

• Personal Author:
  Cho SJ ; Echevarria GC ; Joseph P ; Kwon S ; Naveed B ; Nolan A ; Prezant DJ ; Rom, William N. ; Schenck EJ ; Schmidt AM ; Tsukiji J ; Weiden MD
• Description:
  RATIONALE: Metabolic syndrome, inflammatory and vascular injury markers measured in serum after World Trade Center (WTC) exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV1 < LLN. METHODS: Nested case-control study of WTC-exposed firefighters. Cases had FEV1 < LLN. Controls derived from the baseline cohort. Demographics, pulmonary function, serum lipids, LPA and ApoA1 were measured. RESULTS: LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV1 < LLN in a multivariable model. CONCLUSIONS: Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV1 < LLN. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biomarkers Dust Emergencies Emergency Responders Firefighters Immune System Lung Lung Diseases Occupational Health Particulate Matter Respiratory Function Tests Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety September 11 Terrorist Attacks

  More +
• Keywords:
  Airborne-dusts Airborne-particles Airway-obstruction Author Keywords: Biomarkers Dyslipidemia And Occupational Exposure Emergency-responders Emergency-response Fire-fighters Immunoglobulins Lung-disorders Lung-function Particulate-dust Particulates Pulmonary-function Pulmonary-function-tests Pulmonary-system-disorders Respiratory-system-disorders Risk-factors Serology World Trade Center

  More +
• ISSN:
  1354-750X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  159-165
• Volume:
  19
• Issue:
  2
• NIOSHTIC Number:
  nn:20044240
• Citation:
  Biomarkers 2014 Mar; 19(2):159-165
• Contact Point Address:
  Anna Nolan, MD, MS, Assistant Professor of Medicine and Environmental Medicine, Division of Pulmonary, Critical Care and Sleep, NYU School of Medicine, New Bellevue, 7N Room 24, 462 1st Avenue, New York, NY 10016, USA
• Email:
  anna.nolan@med.nyu.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  New York City Fire Department
• Peer Reviewed:
  True
• Start Date:
  20040701
• Source Full Name:
  Biomarkers
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:64cfeb2c22112f559604f58fd1d40e41a8f08b6cbdd78104ab38cb18d661e50b5973115d934e8d14cca3c528c2b777830de3f2491027c019e7359714a2227563
• Download URL:
  https://stacks.cdc.gov/view/cdc/199990/cdc_199990_DS1.pdf
• File Type:
  [PDF - 556.43 KB ]