Chitotriosidase is a biomarker for the resistance to World Trade Center lung injury in New York City firefighters

Details

• Personal Author:
  Cho SJ ; Echevarria GC ; Kwon S ; Naveed B ; Nolan A ; Prezant DJ ; Rom, William N. ; Schenck E ; Tsukiji J ; Weiden MD
• Description:
  PURPOSE: World Trade Center (WTC) exposure caused airflow obstruction years after exposure. Chitinases and IgE are innate and humoral mediators of obstructive airway disease. We investigated if serum expression of chitinases and IgE early after WTC exposure predicts subsequent obstruction. METHODS: With a nested case-control design, 251 FDNY personnel had chitotriosidase, YKL-40 and IgE measured in serum drawn within months of 9/11/2001. The main outcome was subsequent Forced Expiratory Volume after 1 second/Forced Vital Capacity (FEV1/FVC) less than the lower limit of normal (LLN). Cases (N=125) had abnormal FEV1/FVC whereas controls had normal FEV1/FVC (N=126). In a secondary analysis, resistant cases (N=66) had FEV1 (>/=107 %) one standard deviation above the mean. Logistic regression adjusted for age, BMI, exposure intensity and post-exposure FEV1/FVC modeled the association between early biomarkers and later lung function. RESULTS: Cases and Controls initially lost lung function. Controls recovered to pre-9/11 FEV1 and FVC while cases continue to decline. Cases expressed lower serum chitotriosidase and higher IgE levels. Increase in IgE increased the odds of airflow obstruction and decreased the odds of above average FEV1. Alternately, increasing chitotriosidase decreased the odds of abnormal FEV1/FVC and increased the odds of FEV1 >/=107 %. Serum YKL-40 was not associated with FEV1/FVC or FEV1 in this cohort. CONCLUSIONS: Increased serum chitotriosidase reduces the odds of developing obstruction after WTC-particulate matter exposure and is associated with recovery of lung function. Alternately, elevated IgE is a risk factor for airflow obstruction and progressive lung function decline. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biomarkers Dust Emergencies Emergency Responders Firefighters Immune System Lung Lung Diseases Occupational Health Particulate Matter Respiratory Function Tests Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety

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• Keywords:
  Airborne-dusts Airborne-particles Airway-obstruction Author Keywords: Chitotriosidase Emergency-responders Emergency-response Fire-fighters Immunoglobulin E Immunoglobulins Lung-disorders Lung-function Particulate-dust Particulates Pulmonary-function Pulmonary-function-tests Pulmonary-system-disorders Pulmonary Function Testing Respiratory-system-disorders Risk-factors Serology WTC Particulate Matter

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• ISSN:
  0271-9142
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  33
• Issue:
  6
• NIOSHTIC Number:
  nn:20043098
• Citation:
  J Clin Immunol 2013 Aug; 33(6):1134-1142
• Contact Point Address:
  M. D. Weiden, Medicine and Environmental Medicine, New York University School of Medicine, 550 1st Ave, New York, NY 10016, USA
• Email:
  michael.weiden@med.nyu.edu
• Federal Fiscal Year:
  2013
• Performing Organization:
  New York City Fire Department
• Peer Reviewed:
  False
• Start Date:
  20040701
• Source Full Name:
  Journal of Clinical Immunology
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a3b8473827adc6bfc4193c567a35b17695217018ba4bf01ed922c96237e12d2207405c604de3a26f7d22b8d1595ff6982446b5f2cd4f6ead4ba363a2b3bdf02d
• Download URL:
  https://stacks.cdc.gov/view/cdc/195112/cdc_195112_DS1.pdf
• File Type:
  [PDF - 235.94 KB ]