The identification of a sensitizing component used in the manufacturing of an ink ribbon

Details

• Personal Author:
  Anderson, Stacey E. ; Cohen DE ; Durgam, Srinivas ; Jackson LG ; Meade BJ ; Tapp, Loren C.
• Description:
  Skin diseases including dermatitis constitute approximately 30% of all occupational illnesses, with a high incidence in the printing industry. An outbreak of contact dermatitis among employees at an ink ribbon manufacturing plant was investigated by scientists from the National Institute for Occupational Safety and Health (NIOSH). Employees in the process areas of the plant were exposed to numerous chemicals and many had experienced skin rashes, especially after the introduction of a new ink ribbon product. To identify the causative agent(s) of the occupational dermatitis, the murine local lymph node assay (LLNA) was used to identify the potential of the chemicals used in the manufacture of the ink ribbon to induce allergic contact dermatitis. Follow-up patch testing with the suspected allergens was conducted on exposed employees. Polyvinyl butyral, a chemical component used in the manufacture of the ink ribbon in question and other products, tested positive in the LLNA, with an EC3 of 3.6%, which identifies it as a potential sensitizer; however, no employees tested positive to this chemical during skin patch testing. This finding has implications beyond those described in this report because of occupational exposure to polyvinyl butyral outside of the printing industry. [Description provided by NIOSH]
• Subjects:
  Biological Assay Chemistry Dermatitis Environmental Exposure Hypersensitivity Ink Manufacturing And Industrial Facilities Occupational Health Printing Safety Skin Skin Diseases

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• Keywords:
  Allergens Allergic-dermatitis Allergic-reactions Author Keywords: Polyvinyl Butyral Bioassays Chemical-factory-workers Chemical-hypersensitivity Chemical-processing Chemical-reactions Contact-dermatitis Industrial-exposures Ink Ribbon Manufacturing Local Lymph Node Assay Lymph-nodes Lymphatic-system Occupational Contact Dermatitis Patch-tests Printing-inks Skin-diseases Skin-exposure Skin-irritants Skin-lesions Skin-sensitivity

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• ISSN:
  1547-691X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; Ohio ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  193-200
• Volume:
  9
• Issue:
  2
• NIOSHTIC Number:
  nn:20040431
• Citation:
  J Immunotoxicol 2012 Mar; 9(2):193-200
• Contact Point Address:
  Stacey E. Anderson, PhD, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  sanderson4@cdc.gov
• CAS Registry Number:
  Polyvinyl butyrals (CAS RN 63148-65-2)
• Federal Fiscal Year:
  2012
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Immunotoxicology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d862d2d85f3e7947eb4e48d0edaf59d1d4271aa1abb3ad1cff93b3803c7d1c475524f8b5b8aec5e1f4a1ba6969fbcf331cadf21c139b48844b0a66f018339c69
• Download URL:
  https://stacks.cdc.gov/view/cdc/193296/cdc_193296_DS1.pdf
• File Type:
  [PDF - 800.49 KB ]